通过跨物种进化产生HLA - B*1516/B*1567/B*1595和B*1517等位基因（B15特异性组）
Generation of HLA-B*1516/B*1567/B*1595 and B*1517 alleles (B15 specific group) by transpecies evolution.
作者信息
Román Angela, Cervera Isabel, Head Jacqueline, Rodríguez Miriam, Martínez-Laso Jorge
机构信息
Unidad de Inmunoterapia Celular, Instituto de Salud Carlos III, Centro Nacional de Microbiología, Majadahonda, Madrid, Spain.
出版信息
Hum Immunol. 2007 Dec;68(12):1001-8. doi: 10.1016/j.humimm.2007.10.010. Epub 2007 Nov 26.
The generation of the human leukocyte antigen (HLA)-B1516, B1517, B1567, and B1595 alleles has been analyzed using exon 1, intron 1, exon 2, intron 2, and exon 3 sequences from human and non-human primates. Results showed that at the first place three evolutionary steps would have been necessary for the generation of HLA-B1516 and B1517 alleles: (1) a non-human primate step with the generation of a major histocompatibility complex (MHC)-B1516/1517-like allele; (2) a human or non-human primate step with two different ways of evolution generating a MHC-B1516 and a MHC-B1517 ancestors; and (3) a human step consisting of the generation of HLA-B1516 and HLA-B15170101 alleles. After that, HLA-B1567, B1595 B151701012, and B*151702 alleles would be generated by point mutation events. In conclusion these alleles are generated by two different evolutionary pathways. The generation of these alleles points out the importance of the exons/introns in the generation of the evolution of HLA alleles.
利用人类和非人类灵长类动物的第1外显子、第1内含子、第2外显子、第2内含子和第3外显子序列，对人类白细胞抗原（HLA）-B1516、B1517、B1567和B1595等位基因的产生进行了分析。结果表明，首先，HLA-B1516和B1517等位基因的产生需要三个进化步骤：（1）非人类灵长类动物步骤，产生主要组织相容性复合体（MHC）-B1516/1517样等位基因；（2）人类或非人类灵长类动物步骤，通过两种不同的进化方式产生MHC-B1516和MHC-B1517祖先；（3）人类步骤，包括HLA-B1516和HLA-B15170101等位基因的产生。此后，HLA-B1567、B1595、B151701012和B*151702等位基因将通过点突变事件产生。总之，这些等位基因是由两种不同的进化途径产生的。这些等位基因的产生指出了外显子/内含子在HLA等位基因进化产生中的重要性。
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