Martínez-Laso J, Moscoso J, Zamora J, Gómez-Casado E, Arnaiz-Villena A
Immunology Research Unit, Department of Microbiology, Hospital Clinico San Carlos, Madrid, Spain.
Tissue Antigens. 2006 Jan;67(1):70-4. doi: 10.1111/j.1399-0039.2005.00499.x.
The generation of the B41 alleles has been analysed using exon 1, intron 1, exon 2, intron 2 and exon 3 sequences. Results showed that B4102 may have been generated as the first B41 allele by a recombination mechanism between B400102 and B0801 or B4201 involving intron 2. B4101, B4104 and B4107 alleles could have been generated from B4102 by a gene conversion event taking three different fragments from sequences belonging to intron 2/exon 3 of B45, B50 or B49 alleles. B4105 and B4106 could be generated from B4101 allele by point mutations, and B*4103 generation is unclear due to the lack of intron 2. The importance of introns in HLA-B allele polymorphism generation is stressed.
已使用外显子1、内含子1、外显子2、内含子2和外显子3序列分析了B41等位基因的产生。结果表明，B4102可能是通过B400102与B0801或B4201之间涉及内含子2的重组机制产生的第一个B41等位基因。B4101、B4104和B4107等位基因可能是由B4102通过基因转换事件产生的，该事件从属于B45、B50或B49等位基因的内含子2/外显子3序列中获取了三个不同的片段。B4105和B4106可能是由B4101等位基因通过点突变产生的，由于缺乏内含子2，B*4103的产生尚不清楚。强调了内含子在HLA - B等位基因多态性产生中的重要性。
