洛贝林对强直和甲基苯丙胺诱导的多巴胺释放的影响。
Lobeline effects on tonic and methamphetamine-induced dopamine release.
作者信息
Wilhelm Clare J, Johnson Robert A, Eshleman Amy J, Janowsky Aaron
机构信息
Research Service, Veterans Affairs Medical Center, Portland, OR 97239, USA.
出版信息
Biochem Pharmacol. 2008 Mar 15;75(6):1411-5. doi: 10.1016/j.bcp.2007.11.019. Epub 2007 Dec 4.
Abstract
The mechanisms of interaction between lobeline and the dopamine transporter (DAT) or the vesicular monoamine transporter (VMAT-2) are not clear. The goal of this study was to elucidate the effects of lobeline on these transporters in a cell system co-expressing the DAT and VMAT-2. Lobeline caused release of [(3)H]dopamine to a similar extent as reserpine (VMAT-2 inhibitor), but was less efficacious than methamphetamine or dopamine. Additionally, lobeline decreased the [(3)H]dopamine-releasing effects of methamphetamine, unlike reserpine which increased release by methamphetamine. These results suggest that lobeline has unique properties at the DAT and VMAT-2 which may make it useful as a pharmacotherapeutic to treat methamphetamine abuse.
摘要
洛贝林与多巴胺转运体（DAT）或囊泡单胺转运体（VMAT-2）之间的相互作用机制尚不清楚。本研究的目的是在共表达DAT和VMAT-2的细胞系统中阐明洛贝林对这些转运体的影响。洛贝林引起的[³H]多巴胺释放程度与利血平（VMAT-2抑制剂）相似，但效力低于甲基苯丙胺或多巴胺。此外，与利血平增加甲基苯丙胺的释放不同，洛贝林降低了甲基苯丙胺的[³H]多巴胺释放作用。这些结果表明，洛贝林在DAT和VMAT-2上具有独特的性质，这可能使其成为治疗甲基苯丙胺滥用的有效药物。
相似文献
1
Lobeline effects on tonic and methamphetamine-induced dopamine release.洛贝林对强直和甲基苯丙胺诱导的多巴胺释放的影响。
Biochem Pharmacol. 2008 Mar 15;75(6):1411-5. doi: 10.1016/j.bcp.2007.11.019. Epub 2007 Dec 4.
2
Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.洛贝林通过抑制囊泡单胺转运体 2 抑制甲基苯丙胺诱导的多巴胺释放。
J Pharmacol Exp Ther. 2010 Feb;332(2):612-21. doi: 10.1124/jpet.109.160275. Epub 2009 Oct 23.
3
GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine.GZ-793A，一种贝壳杉烷类似物，与囊泡单胺转运体-2 相互作用，抑制 methamphetamine 的作用。
J Neurochem. 2013 Oct;127(2):177-86. doi: 10.1111/jnc.12371. Epub 2013 Aug 19.
4
Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.新型 N-1,2-二羟丙基半边莲生物碱类似物抑制囊泡单胺转运体 2 功能和甲基苯丙胺诱导的多巴胺释放。
J Pharmacol Exp Ther. 2011 Oct;339(1):286-97. doi: 10.1124/jpet.111.184770. Epub 2011 Jul 21.
5
Effects of methamphetamine and lobeline on vesicular monoamine and dopamine transporter-mediated dopamine release in a cotransfected model system.甲基苯丙胺和洛贝林对共转染模型系统中囊泡单胺和多巴胺转运体介导的多巴胺释放的影响。
J Pharmacol Exp Ther. 2004 Sep;310(3):1142-51. doi: 10.1124/jpet.104.067314. Epub 2004 Apr 21.
6
The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse.囊泡单胺转运体-2：发现治疗甲基苯丙胺滥用新疗法的重要药理学靶点。
Adv Pharmacol. 2014;69:71-106. doi: 10.1016/B978-0-12-420118-7.00002-0.
7
Quinolyl analogues of norlobelane: novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2.去甲劳丹碱的喹啉类似物：新型强效囊泡单胺转运体-2上[(3)H]二氢丁苯那嗪结合和[(3)H]多巴胺摄取的抑制剂
Bioorg Med Chem Lett. 2015 Jul 1;25(13):2613-6. doi: 10.1016/j.bmcl.2015.04.105. Epub 2015 May 9.
8
The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats.新型吡咯烷诺洛贝林类似物 UKCP-110[顺式-2,5-二-(2-苯乙基)-吡咯烷盐酸盐]抑制 VMAT2 功能、苯丙胺诱发的多巴胺释放和大鼠苯丙胺自我给药。
J Pharmacol Exp Ther. 2010 Dec;335(3):841-51. doi: 10.1124/jpet.110.172742. Epub 2010 Aug 30.
9
Lobeline attenuates methamphetamine-induced changes in vesicular monoamine transporter 2 immunoreactivity and monoamine depletions in the striatum.洛贝林可减轻甲基苯丙胺引起的纹状体中囊泡单胺转运体2免疫反应性变化和单胺耗竭。
J Pharmacol Exp Ther. 2005 Jan;312(1):160-9. doi: 10.1124/jpet.104.072264. Epub 2004 Aug 26.
10
Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain.通过对果蝇大脑中多巴胺突触小泡的光学监测阐明苯丙胺的作用机制。
Nat Commun. 2016 Feb 16;7:10652. doi: 10.1038/ncomms10652.
引用本文的文献
1
Phenotype-Based HPLC-Q-TOF-MS/MS Coupled With Zebrafish Behavior Trajectory Analysis System for the Identification of the Antidepressant Components in Methanol Extract of Anshen Buxin Six Pills.基于表型的高效液相色谱-四极杆飞行时间串联质谱联用斑马鱼行为轨迹分析系统用于鉴定安神补心六味丸甲醇提取物中的抗抑郁成分
Front Pharmacol. 2021 Nov 22;12:764388. doi: 10.3389/fphar.2021.764388. eCollection 2021.
2
Target-directed evolution of novel modulators of the dopamine transporter in Lobelia cardinalis hairy root cultures.在半边莲毛状根培养物中靶向进化多巴胺转运体的新型调节剂。
J Biotechnol. 2021 Dec 10;342:28-35. doi: 10.1016/j.jbiotec.2021.10.001. Epub 2021 Oct 12.
3
Increased Absolute Glutamate Concentrations and Glutamate-to-Creatine Ratios in Patients With Methamphetamine Use Disorders.甲基苯丙胺使用障碍患者的绝对谷氨酸浓度和谷氨酸与肌酸比值升高。
Front Psychiatry. 2018 Aug 31;9:368. doi: 10.3389/fpsyt.2018.00368. eCollection 2018.
4
Development of serotonin transporter reuptake inhibition assays using JAR cells.利用JAR细胞开发5-羟色胺转运体再摄取抑制试验。
J Pharmacol Toxicol Methods. 2018 Jul-Aug;92:52-56. doi: 10.1016/j.vascn.2018.03.003. Epub 2018 Mar 16.
5
New Scaffold for Lead Compounds to Treat Methamphetamine Use Disorders.治疗甲基苯丙胺使用障碍的先导化合物新支架。
AAPS J. 2018 Feb 9;20(2):29. doi: 10.1208/s12248-018-0192-y.
6
Modulation of aggressive behavior in mice by nicotinic receptor subtypes.烟碱受体亚型对小鼠攻击行为的调节作用。
Biochem Pharmacol. 2015 Oct 15;97(4):488-497. doi: 10.1016/j.bcp.2015.07.019. Epub 2015 Jul 23.
7
Argon blocks the expression of locomotor sensitization to amphetamine through antagonism at the vesicular monoamine transporter-2 and mu-opioid receptor in the nucleus accumbens.氩通过伏隔核中囊泡单胺转运体2和μ-阿片受体的拮抗作用，阻断对苯丙胺运动致敏的表达。
Transl Psychiatry. 2015 Jul 7;5(7):e594. doi: 10.1038/tp.2015.27.
8
The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse.囊泡单胺转运体-2：发现治疗甲基苯丙胺滥用新疗法的重要药理学靶点。
Adv Pharmacol. 2014;69:71-106. doi: 10.1016/B978-0-12-420118-7.00002-0.
9
Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo.VMAT2 抑制剂洛贝林和 GZ-793A 对体内甲基苯丙胺引起的多巴胺释放、代谢和合成变化的影响。
J Neurochem. 2013 Oct;127(2):187-98. doi: 10.1111/jnc.12373. Epub 2013 Aug 20.
10
The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy. sarcospan 在黏附复合物替换治疗肌营养不良症中的潜力。
FEBS J. 2013 Sep;280(17):4210-29. doi: 10.1111/febs.12295. Epub 2013 May 13.
本文引用的文献
1
Approaches to the development of medications for the treatment of methamphetamine dependence.用于治疗甲基苯丙胺成瘾的药物研发方法。
Addiction. 2007 Apr;102 Suppl 1:96-106. doi: 10.1111/j.1360-0443.2007.01772.x.
2
Mechanisms of neurotransmitter release by amphetamines: a review.安非他明释放神经递质的机制：综述
Prog Neurobiol. 2005 Apr;75(6):406-33. doi: 10.1016/j.pneurobio.2005.04.003.
3
Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.对质膜和囊泡单胺转运体具有增强亲和力和选择性的洛贝林类似物。
J Pharmacol Exp Ther. 2004 Sep;310(3):1035-45. doi: 10.1124/jpet.104.068098. Epub 2004 Apr 30.
4
Effects of methamphetamine and lobeline on vesicular monoamine and dopamine transporter-mediated dopamine release in a cotransfected model system.甲基苯丙胺和洛贝林对共转染模型系统中囊泡单胺和多巴胺转运体介导的多巴胺释放的影响。
J Pharmacol Exp Ther. 2004 Sep;310(3):1142-51. doi: 10.1124/jpet.104.067314. Epub 2004 Apr 21.
5
Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum.人类纹状体中多巴胺及其他突触前多巴胺能标志物的年龄相关变化存在显著差异。
J Neurochem. 2003 Nov;87(3):574-85. doi: 10.1046/j.1471-4159.2003.02017.x.
6
Lobeline does not serve as a reinforcer in rats.洛贝林对大鼠而言并非强化物。
Psychopharmacology (Berl). 2003 Feb;165(4):397-404. doi: 10.1007/s00213-002-1289-6. Epub 2002 Nov 30.
7
A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse.洛贝林作为治疗精神兴奋剂滥用的一种新作用机制及潜在用途。
Biochem Pharmacol. 2002 Jan 15;63(2):89-98. doi: 10.1016/s0006-2952(01)00899-1.
8
Lobeline attenuates d-methamphetamine self-administration in rats.洛贝林可减弱大鼠对右旋苯丙胺的自我给药行为。
J Pharmacol Exp Ther. 2001 Jul;298(1):172-9.
9
Lobeline inhibits the neurochemical and behavioral effects of amphetamine.洛贝林抑制苯丙胺的神经化学和行为效应。
J Pharmacol Exp Ther. 2001 Mar;296(3):1023-34.
10
Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles: comparison with d-amphetamine.洛贝林可取代[3H]二氢丁苯那嗪的结合，并从大鼠纹状体突触小泡中释放[3H]多巴胺：与d-苯丙胺的比较。
J Neurochem. 1998 Jul;71(1):258-65. doi: 10.1046/j.1471-4159.1998.71010258.x.
Zotero 插件