Klipcan Liron, Frenkel-Morgenstern Milana, Safro Mark G
Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Trends Genet. 2008 Feb;24(2):59-63. doi: 10.1016/j.tig.2007.11.007. Epub 2008 Jan 14.
Archeal proteomes can be clustered into two groups based on their cysteine content. One group of proteomes displays a low cysteine content ( approximately 0.7% of the entire proteome), whereas the second group contains twice as many cysteines as the first ( approximately 1.3%). All cysteine-rich organisms belong to the methanogenic Archaea, which generates special cysteine clusters associated with primitive metabolic reactions. Our findings suggest that cysteine plays an important role in early forms of life.
古菌蛋白质组可根据其半胱氨酸含量分为两组。一组蛋白质组的半胱氨酸含量较低（约占整个蛋白质组的0.7%），而另一组的半胱氨酸含量是第一组的两倍（约1.3%）。所有富含半胱氨酸的生物都属于产甲烷古菌，它们会产生与原始代谢反应相关的特殊半胱氨酸簇。我们的研究结果表明，半胱氨酸在生命的早期形式中起着重要作用。
