Russo V, Borzacchiello G, Brun R, D'Ischia M, Napolitano A, Paciello O, Panzella L, Roperto F, Urraro C, Roperto S
Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy.
Vet Pathol. 2008 Jan;45(1):46-50. doi: 10.1354/vp.45-1-46.
Melanosis of the urinary bladder is a very rare condition characterized by an abnormal black or brownish-black pigmentation of the organ. The pigmentary disorder can involve both the urothelial cell layers and/or the submucosa. The biologic potential of the melanosis of urinary bladder remains unknown because only a few cases have been reported in medical literature. So far melanosis of the urinary bladder is not known to occur in cattle. Here we describe the first case of melanosis of the urinary bladder in an inbred red-spotted, 7-year-old cow. Light, ultrastructural, and immunohistochemic investigations demonstrated melanin pigment in the submucosa and lamina propria but not the urothelium of the bladder. In addition, biochemical characterization of the pigment-laden cells demonstrated that the pigment of this disorder consisted mainly of eumelanin, thus corroborating the morphologic studies. Finally, virologic examination revealed the presence of bovine papillomavirus type 2.
膀胱黑变病是一种非常罕见的病症，其特征是膀胱器官出现异常的黑色或棕黑色色素沉着。色素沉着紊乱可累及尿路上皮层和/或黏膜下层。由于医学文献中仅报道了少数病例，膀胱黑变病的生物学潜能仍不明确。到目前为止，尚未发现牛会发生膀胱黑变病。在此，我们描述了首例发生在一只7岁近交红斑牛身上的膀胱黑变病病例。光学、超微结构和免疫组织化学研究表明，黑色素存在于黏膜下层和固有层，而非膀胱尿路上皮层。此外，对富含色素细胞的生化特性分析表明，该病症的色素主要由真黑素组成，从而证实了形态学研究结果。最后，病毒学检查发现了2型牛乳头瘤病毒。
