从印度楝树印楝中合成天然产物。

Synthesis of natural products from the Indian neem tree Azadirachta indica.

作者信息

Veitch Gemma E, Pinto Andrea, Boyer Alistair, Beckmann Edith, Anderson James C, Ley Steven V

机构信息

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

出版信息

Org Lett. 2008 Feb 21;10(4):569-72. doi: 10.1021/ol7027898. Epub 2008 Jan 15.

DOI:10.1021/ol7027898

PMID:18193879

Abstract

The synthesis of five natural products (3, 6, 7, 10, and 14), isolated from the Indian neem tree Azadirachta indica, is reported from a common intermediate (2). The judicious choice of transacetalization conditions allows efficient access to both the azadirachtinin (9 and 10) and the azadirachtin (3, 6, 7, and 14) skeletons.

摘要

据报道，从印度楝树印楝（Azadirachta indica）中分离出的五种天然产物（3、6、7、10和14）可由一个共同中间体（2）合成。通过明智地选择缩醛交换条件，可以有效地构建印楝素（9和10）和印楝素（3、6、7和14）骨架。