Hamilton Chad A, Kapp Daniel S, Chan John K
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Walter Reed Army Medical Center, Washington, District of Columbia, USA.
Curr Opin Obstet Gynecol. 2008 Feb;20(1):26-33. doi: 10.1097/GCO.0b013e3282f2b10d.
We review the demographic and clinicopathologic characteristics, and prognosis of women diagnosed with uterine papillary serous carcinoma, with a focus on clinical management.
Pathologic evaluation of postmenopausal bleeding is preferred for patients who fit the profile of a high-risk endometrial cancer such as uterine papillary serous carcinoma. Women diagnosed with endometrial cancer who fit this profile and all women with uterine papillary serous carcinoma should undergo comprehensive surgical staging and aggressive cytoreduction of extrauterine disease. Adjuvant therapy remains controversial. Several recent investigations reported on the potential benefit of adjuvant chemotherapy, with many recommending additional loco-regional radiation.
Despite the lack of randomized trials on uterine papillary serous carcinoma, several recent reports have provided insight into the diagnosis, surgical management, and adjuvant treatment of this high-risk endometrial cancer.
我们回顾了诊断为子宫浆液性乳头状癌的女性的人口统计学和临床病理特征以及预后情况，重点关注临床管理。
对于符合高危子宫内膜癌特征（如子宫浆液性乳头状癌）的患者，绝经后出血的病理评估更为可取。诊断为符合该特征的子宫内膜癌的女性以及所有子宫浆液性乳头状癌女性均应接受全面的手术分期和对子宫外疾病进行积极的细胞减灭术。辅助治疗仍存在争议。最近的几项研究报告了辅助化疗的潜在益处，许多人建议增加局部区域放疗。
尽管缺乏关于子宫浆液性乳头状癌的随机试验，但最近的几份报告为这种高危子宫内膜癌的诊断、手术管理和辅助治疗提供了见解。
