Rudnicki M
Department of Internal Medicine, Hvidovre Hospital, University of Copenhagen, Denmark.
Miner Electrolyte Metab. 1991;17(5):331-4.
Serial determinations (n = 5-13) of serum ionized calcium and intact parathyroid hormone (PTH) were performed in 12 patients with chronic surgical hypoparathyroidism during 1-2 years of their long-term replacement therapy. Average serum ionized calcium ranged from 1.04 to 1.20 mmol/l (normal range 1.15-1.35 mmol/l) and all had detectable levels of PTH. In hypocalcemic patients a significant inverse relationship between serum concentrations of ionized calcium and PTH was observed. Apparently, the remaining parathyroid glands responded to hypocalcemia by increasing PTH secretion. Thus, the stage is set for a compensatory hypertrophy, but the concentration of PTH remains fairly low for unknown reasons. Maybe treatment with vitamin D would prevent such hypertrophy.
在12例慢性手术性甲状旁腺功能减退患者长期替代治疗的1至2年期间，进行了血清离子钙和完整甲状旁腺激素（PTH）的系列测定（n = 5 - 13）。血清离子钙平均范围为1.04至1.20 mmol/L（正常范围1.15 - 1.35 mmol/L），且所有患者的PTH水平均可检测到。在低钙血症患者中，观察到离子钙血清浓度与PTH之间存在显著的负相关关系。显然，剩余的甲状旁腺通过增加PTH分泌对低钙血症做出反应。因此，已具备代偿性肥大的条件，但PTH浓度因不明原因仍相当低。或许用维生素D治疗可预防这种肥大。
