Pivina S G, Shamolina T S, Akulova V K, Ordian N E
Ross Fiziol Zh Im I M Sechenova. 2007 Nov;93(11):1319-25.
The sensitiveness of female rats to social stress induced by increasing group density, was investigated. It was shown that female rats were housed in groups of 9-10 animala per cage in pubertal period and demonstrated significant alteration of oestrous cycle duration and anxiety level. This housing condition increased basal level of corticostcrone in prenatal stressed female rats who have high stress reactivity of the hypothalamic-pituitary-adrenal axis, as well as a more profound effect on anxiety level and oestrous cycle. Prenatal stressed rats retained impairment of oestrous cycle and behavior after optimization of housing condition, whereas control rats demonstrated normalization of oestrous cycle duration and anxiety level. These data suggest that high stress reactivity females rats are more sensitive to crowding-induced stress.
研究了雌性大鼠对因群体密度增加而引起的社会应激的敏感性。结果表明，青春期雌性大鼠每笼饲养9 - 10只，其发情周期持续时间和焦虑水平出现显著改变。这种饲养条件增加了下丘脑 - 垂体 - 肾上腺轴具有高应激反应性的产前应激雌性大鼠的皮质酮基础水平，并且对焦虑水平和发情周期有更深远的影响。优化饲养条件后，产前应激大鼠的发情周期和行为仍存在损伤，而对照大鼠的发情周期持续时间和焦虑水平则恢复正常。这些数据表明，高应激反应性的雌性大鼠对拥挤诱导的应激更为敏感。
