毛里求斯岛食蟹猴（猕猴）的遗传多样性：核DNA和线粒体DNA多态性评估
Genetic diversity of longtail macaques (Macaca fascicularis) on the island of Mauritius: an assessment of nuclear and mitochondrial DNA polymorphisms.
作者信息
Kawamoto Y, Kawamoto S, Matsubayashi K, Nozawa K, Watanabe T, Stanley M-A, Perwitasari-Farajallah D
机构信息
Primate Research Institute, Kyoto University, Aichi, Japan.
出版信息
J Med Primatol. 2008 Feb;37(1):45-54. doi: 10.1111/j.1600-0684.2007.00225.x.
BACKGROUND
Individuals from an introduced population of longtail macaques on Mauritius have been extensively used in recent research. This population has low MHC gene diversity, and is thus regarded as a valuable resource for research.
METHODS
We investigated the genetic diversity of this population using multiple molecular markers located in mitochondrial DNA and microsatellite DNA loci on the autosomes and the Y chromosome. We tested samples from 82 individuals taken from seven study sites.
RESULTS AND CONCLUSIONS
We found this population to be panmictic, with a low degree of genetic variability. On the basis of an mtDNA phylogeny, we inferred that these macaques' ancestors originated from Java in Asia. Weak gametic disequilibrium was observed, suggesting decay of non-random associations between genomic genes at the time of founding. The results suggest that macaques bred in Mauritius are valuable as model animals for biomedical research because of their genetic homogeneity.
背景
毛里求斯长尾猕猴引入种群的个体在最近的研究中被广泛使用。该种群的主要组织相容性复合体（MHC）基因多样性较低，因此被视为有价值的研究资源。
方法
我们使用位于线粒体DNA以及常染色体和Y染色体上的微卫星DNA位点的多个分子标记，研究了该种群的遗传多样性。我们检测了来自七个研究地点的82个个体的样本。
结果与结论
我们发现该种群是随机交配的，遗传变异性程度较低。基于线粒体DNA系统发育，我们推断这些猕猴的祖先起源于亚洲的爪哇。观察到弱配子不平衡，表明在种群建立时基因组基因之间的非随机关联衰减。结果表明，在毛里求斯繁殖的猕猴因其遗传同质性，作为生物医学研究的模式动物具有重要价值。
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