Adriaenssens Eric, Vanhecke Elsa, Saule Pasquine, Mougel Alexandra, Page Adeline, Romon Rodrigue, Nurcombe Victor, Le Bourhis Xuefen, Hondermarck Hubert
INSERM U908, Institut National de la Sante et de la Recherche Medicale, University Lille 1, Lille, France.
Cancer Res. 2008 Jan 15;68(2):346-51. doi: 10.1158/0008-5472.CAN-07-1183.
We show here that nerve growth factor (NGF), the prototypic neurotrophin, can be targeted in breast cancer to inhibit tumor cell proliferation, survival, and metastasis. Analysis of a series of biopsies revealed widespread expression of NGF in the majority of human breast tumors, with anti-NGF immunoreactivity concentrated in the epithelial cancer cells. Moreover, immunodeficient mice xenografted with human breast cancer cells and treated with either anti-NGF antibodies or small interfering RNA against NGF displayed inhibited tumor growth and metastasis. Such treatments directed against NGF induced a decrease in cell proliferation with a concomitant increase in apoptosis of breast cancer cells and an inhibition of tumor angiogenesis. Together, these data indicate that targeting NGF in breast cancer may have therapeutic ramifications.
我们在此表明，作为典型神经营养因子的神经生长因子（NGF）可成为乳腺癌治疗靶点，以抑制肿瘤细胞增殖、存活及转移。对一系列活检样本的分析显示，NGF在大多数人类乳腺肿瘤中广泛表达，抗NGF免疫反应集中在上皮癌细胞中。此外，用人乳腺癌细胞异种移植并接受抗NGF抗体或针对NGF的小干扰RNA治疗的免疫缺陷小鼠，其肿瘤生长和转移受到抑制。针对NGF的此类治疗导致细胞增殖减少，同时乳腺癌细胞凋亡增加，并抑制肿瘤血管生成。这些数据共同表明，针对乳腺癌中的NGF可能具有治疗意义。
