Jiménez-Balderas F J, Solís J L, Mintz G
Depto. de Reumatología, Hosp. de Especialidades, Centro Médico Nacional, Instituto Mexicano del Seguro Social, D.F.
Arch Invest Med (Mex). 1991 Apr-Jun;22(2):121-5.
Serum glucose, serum immunoreactive insulin and sedimentation rate (ESR) were measured in eighteen male patients with ankylosing spondylitis (AS) and seven male healthy controls. The findings were correlated with the presence or absence of inflammatory activity of the disease. Fourteen patients had active AS with ESR of 47.0 +/- 27.7 mm; they had increased insulin levels measured as area under curve (AUC) of a glucose tolerance test 107.4 +/- 44.1 cm2 vs controls 40.8 +/- 12.6 cm2 (p less than 0.03). In 4 patients with clinically inactive AS and with ESR of 17.0 +/- 4.0 mm the insulin levels as the AUC were 83.2 +/- 38.0 cm2 vs controls (p = ns). In the whole group there was a direct correlation between ESR and serum immunoreactive insulin levels (r = 0.47 p less than 0.05). Our study suggests that AS may be associated with hyperinsulinism, whose role in the physiopathogenesis of the disease remains unknown.
对18例男性强直性脊柱炎（AS）患者和7例男性健康对照者测量了血清葡萄糖、血清免疫反应性胰岛素和血沉率（ESR）。研究结果与疾病炎症活动的有无相关。14例活动性AS患者的ESR为47.0±27.7mm；他们的胰岛素水平升高，以葡萄糖耐量试验曲线下面积（AUC）衡量，为107.4±44.1cm²，而对照组为40.8±12.6cm²（p<0.03）。4例临床非活动性AS患者且ESR为17.0±4.0mm，其作为AUC的胰岛素水平为83.2±38.0cm²，与对照组相比（p=无显著性差异）。在整个研究组中，ESR与血清免疫反应性胰岛素水平之间存在直接相关性（r=0.47，p<0.05）。我们的研究表明，AS可能与高胰岛素血症有关，其在该疾病发病机制中的作用尚不清楚。
