P19胚胎癌细胞神经分化过程中的全基因组去甲基化
Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells.
作者信息
Hatada Izuho, Morita Sumiyo, Kimura Mika, Horii Takuro, Yamashita Riu, Nakai Kenta
机构信息
Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, 371-8512, Japan.
Laboratory of Functional Analysis in silico, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
出版信息
J Hum Genet. 2008;53(2):185-191. doi: 10.1007/s10038-007-0228-0. Epub 2008 Jan 17.
Epigenetic regulation including DNA methylation plays an important role in several differentiation processes. We profiled global DNA methylation in the neural differentiation of P19 embryonic carcinoma cells using a microarray-based method called MIAMI. We found a genome-wide demethylation of genes. This suggests demethylation rather than methylation is important in neural differentiation.
包括DNA甲基化在内的表观遗传调控在多个分化过程中发挥着重要作用。我们使用一种名为MIAMI的基于微阵列的方法，对P19胚胎癌细胞神经分化过程中的全基因组DNA甲基化进行了分析。我们发现基因在全基因组范围内发生去甲基化。这表明去甲基化而非甲基化在神经分化中起重要作用。
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