Anghelescu N, Petrescu A, Alexandrescu I
Institute of Neurology and Psychiatry, Bucharest, Romania.
Rom J Neurol Psychiatry. 1991 Jul-Dec;29(3-4):159-67.
Experimental spinal cord trauma was performed intraoperatively in 132 rabbits (Allen's method modified by Faden et al.). Only 77 animals were administered drugs (glucocorticoids, antioxidants and anti-inflammatory nonsteroids): Prednisolon, Fluocinolon-N-spray, Epurox, Ketazone, Rheopyrin and Rengasil. The remaining 55 animals were controls. Results were clinically (the assessment of lower limb movement was performed on a 5-score scale) and neuropathologically studied. From a clinical point of view, Prednisolon, Fluocinolon and Rengasil showed some beneficial effects. No significant differences of nervous fibre regeneration were noticed between probands and controls.
对132只兔子进行了实验性脊髓损伤手术（采用Faden等人改良的Allen方法）。仅对77只动物给药（糖皮质激素、抗氧化剂和抗炎非甾体类药物）：泼尼松龙、氟轻松 - N - 喷雾剂、依普罗克斯、酮唑、瑞吡林和任加西尔。其余55只动物作为对照。从临床（采用5分制对下肢运动进行评估）和神经病理学方面对结果进行了研究。从临床角度来看，泼尼松龙、氟轻松和任加西尔显示出一些有益效果。在试验组和对照组之间未观察到神经纤维再生的显著差异。
