曲霉病管理中的不断演变的策略。

Evolving strategies in the management of aspergillosis.

作者信息

Magill Shelley S, Chiller Tom M, Warnock David W

机构信息

Centers for Disease Control and Prevention, Mycotic Diseases Branch, Division of Foodborne, Bacterial and Mycotic Diseases, 1600 Clifton Road, Mailstop C-09, Atlanta, GA 30333, USA.

出版信息

Expert Opin Pharmacother. 2008 Feb;9(2):193-209. doi: 10.1517/14656566.9.2.193.

DOI:10.1517/14656566.9.2.193

PMID:18201144

Abstract

Aspergillus spp. remain the most common causes of invasive mould infections among patients with hematologic malignancies and recipients of solid-organ and hematopoietic stem-cell transplants. Despite advances in prevention and treatment, invasive aspergillosis continues to be a deadly disease. This paper reviews current approaches to treatment of aspergillosis in adults, including surgical and immune-based strategies, and developments in prophylaxis for aspergillosis in high-risk patient populations.

摘要

曲霉属仍然是血液系统恶性肿瘤患者以及实体器官和造血干细胞移植受者侵袭性霉菌感染的最常见病因。尽管在预防和治疗方面取得了进展，但侵袭性曲霉病仍然是一种致命疾病。本文综述了成人曲霉病的当前治疗方法，包括手术和基于免疫的策略，以及高危患者群体曲霉病预防的进展。