Jensen Jeffrey T, Archer David F
Oregon Health & Science University, Department of Ob/Gyn, UHN-70, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.
Expert Opin Pharmacother. 2008 Feb;9(2):319-27. doi: 10.1517/14656566.9.2.319.
Considerable recent interest has focused on new methods of delivery of oral contraceptives that reduce or eliminate the hormone-free interval in order to improve convenience and acceptability, but maintain contraceptive efficacy, minimize side effects and reduce or eliminate the frequency of withdrawal bleeding episodes. Studies in several countries, including the US, have documented that many women would prefer to have no episodes of withdrawal bleeding when using oral contraceptives. This review focuses on a unique oral contraceptive formulation containing levonogestrel 90 microg and ethinyl estradiol 20 microg, approved for use in a continuous dosing regimen designed to eliminate withdrawal bleeding throughout the entire year.
最近,人们对口服避孕药的新给药方法产生了浓厚兴趣,这些方法可减少或消除无激素间隔期,以提高便利性和可接受性,同时保持避孕效果,将副作用降至最低,并减少或消除撤退性出血事件的发生频率。包括美国在内的几个国家的研究表明,许多女性在使用口服避孕药时希望不出现撤退性出血情况。本综述聚焦于一种独特的口服避孕药配方,其含有90微克左炔诺孕酮和20微克炔雌醇,已获批用于一种连续给药方案,该方案旨在消除全年的撤退性出血。