Schofield C J, Ellis J D, Ellingford A, Morris A D, Leese G P
Diabetes Centre, Ninewells Hospital and Medical School, Dundee, UK.
Diabet Med. 2008 Feb;25(2):129-33. doi: 10.1111/j.1464-5491.2007.02330.x. Epub 2008 Jan 14.
To ascertain which perifoveal changes on digital retinal screening in diabetes predict the need for subsequent macular grid or focal laser therapy.
Between 1 January 2004 and 31 December 2005, all consecutive retinal images where any lesion was within one disc diameter of the fovea were reviewed. Patients were categorized by lesion at screening as having microaneurysm, single blot haemorrhage, multiple blot haemorrhages and exudates or circinate exudates within one disc diameter of the fovea. We compared these retinal images with the findings on slit lamp examination and the related decision for laser photocoagulation.
Four hundred and twenty-four retinal images were identified. Of these, 52 were excluded, principally because of an interval between photography and clinic attendance of greater than 120 days, leaving 372 retinal images in the study group (313 patients). No patients with a single blot haemorrhage required immediate laser therapy at ophthalmology review compared with 13 (23%) of those with multiple blot haemorrhages and 36 (16%) of those with exudates or circinate lesions (P < 0.001). Thirty-nine patients with a single blot haemorrhage who did not require laser therapy underwent ongoing follow-up. None of these underwent laser therapy for maculopathy within the study time frame (9 months from initial screening event).
In this study, no patients with a single blot haemorrhage within one disc diameter of the fovea on digital retinal screening required laser treatment.
确定糖尿病患者数字视网膜筛查中黄斑周围的哪些变化可预测后续黄斑格栅或局部激光治疗的必要性。
在2004年1月1日至2005年12月31日期间,对所有连续的视网膜图像进行回顾,这些图像中任何病变均位于黄斑中心凹一个视盘直径范围内。患者在筛查时根据病变情况分为黄斑中心凹一个视盘直径范围内有微动脉瘤、单个点状出血、多个点状出血及渗出或环状渗出。我们将这些视网膜图像与裂隙灯检查结果及相关的激光光凝治疗决策进行比较。
共识别出424张视网膜图像。其中52张被排除,主要原因是摄影与就诊间隔大于120天,研究组剩下372张视网膜图像(313例患者)。眼科复查时,单个点状出血的患者中无人需要立即进行激光治疗,而多个点状出血的患者中有13例(23%)需要,有渗出或环状病变的患者中有36例(16%)需要(P<0.001)。39例单个点状出血且不需要激光治疗的患者接受了持续随访。在研究时间段内(从初次筛查事件起9个月),这些患者中无人因黄斑病变接受激光治疗。
在本研究中,数字视网膜筛查显示黄斑中心凹一个视盘直径范围内有单个点状出血的患者均无需激光治疗。