Goldberg Lynne J, Sekhri Vinoo, Bhawan Jag
Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA.
J Cutan Pathol. 2008 Aug;35(8):757-60. doi: 10.1111/j.1600-0560.2007.00875.x. Epub 2008 Jan 14.
Alopecia areata is an autoimmune disease causing patchy hair loss, which occurs with an increased incidence in patients with lupus erythematosus. We report a 27-year-old African-American female with systemic lupus erythematosus and alopecia areata, whose biopsy showed a marked increase in mucin in the deep dermis and subcutis. Archival biopsies of alopecia areata were then reviewed to see if this finding occurs in patients without systemic lupus. Of 13 recent biopsies diagnostic of alopecia areata, we detected deposition of mucin in 3 (23%), but all mild in degree and in a superficial location. We speculate that the marked deposition of mucin in this patient's biopsy of alopecia areata may be related to her underlying systemic lupus, and that the presence of marked, deep dermal deposition of mucin might serve as a diagnostic clue for the presence of underlying systemic lupus in patients with alopecia areata.
斑秃是一种导致局部脱发的自身免疫性疾病，在红斑狼疮患者中的发病率有所增加。我们报告了一名27岁的非裔美国女性，患有系统性红斑狼疮和斑秃，其活检显示真皮深层和皮下组织中的粘蛋白显著增加。随后对存档的斑秃活检样本进行了复查，以查看这一发现是否出现在无系统性红斑狼疮的患者中。在最近诊断为斑秃的13例活检样本中，我们在3例（23%）中检测到了粘蛋白沉积，但程度均较轻且位于浅表部位。我们推测，该患者斑秃活检中粘蛋白的显著沉积可能与其潜在的系统性红斑狼疮有关，并且真皮深层显著的粘蛋白沉积可能作为斑秃患者潜在系统性红斑狼疮存在的诊断线索。
