Concha Josef Symon Salgado, Werth Victoria P
Corporal Michael J Crescenz VAMC, Philadelphia, Pennsylvania, USA.
Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Lupus Sci Med. 2018 Oct 25;5(1):e000291. doi: 10.1136/lupus-2018-000291. eCollection 2018.
Several patterns of hair loss can occur in lupus erythematosus (LE). Alopecias which show histological characteristics of LE are LE-specific, and include discoid LE (DLE), diffuse or patchy hair loss in acute LE, subacute cutaneous LE, and rarely tumid LE. Lupus hair in SLE is a poorly characterised entity and may be a form of telogen effluvium. Alopecia areata can coexist with LE and may mimic DLE. Non-lupus alopecias such as telogen effluvium and anagen effluvium have a myriad of causes which include disease flares, drugs and stress in the setting of LE. The latest validated Systemic Lupus International Collaborating Clinics classification criteria for SLE includes non-scarring alopecia as a criterion; therefore, recognising the aetiology of hair loss in the setting of LE is crucial in classifying a patient to have systemic disease.
红斑狼疮(LE)可出现多种脱发模式。具有LE组织学特征的脱发是LE特异性的,包括盘状红斑狼疮(DLE)、急性LE中的弥漫性或斑片状脱发、亚急性皮肤型LE,以及罕见的肿胀性LE。系统性红斑狼疮(SLE)中的狼疮性脱发是一种特征不明确的情况,可能是休止期脱发的一种形式。斑秃可与LE共存,且可能类似DLE。非狼疮性脱发,如休止期脱发和生长期脱发,有多种原因,包括LE病情发作、药物和压力等。最新验证的系统性红斑狼疮国际协作临床分类标准将非瘢痕性脱发纳入其中作为一项标准;因此,在LE背景下认识脱发的病因对于将患者分类为患有系统性疾病至关重要。