隆突性皮肤纤维肉瘤和巨细胞成纤维细胞瘤表现为CD99阳性。

Dermatofibrosarcoma protuberans and giant cell fibroblastoma exhibit CD99 positivity.

作者信息

Diwan A Hafeez, Skelton Henry G, Horenstein Marcelo G, Kelly David R, Barrett Terry L, Bussian Anne H, Sanders Deborah Y, Lazar Alexander J F, Prieto Victor G, Smith Kathleen J

机构信息

Department of Pathology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

出版信息

J Cutan Pathol. 2008 Jul;35(7):647-50. doi: 10.1111/j.1600-0560.2007.00872.x. Epub 2008 Jan 14.

DOI:10.1111/j.1600-0560.2007.00872.x

PMID:18201229

Abstract

According to most authors, dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) represent the adult and juvenile forms, respectively, of the same disease entity, as evidenced by similar morphology, an identical chromosomal translocation, and CD34 positivity. It has been shown that DFSP and nuchal-type fibroma (NTF) (which is also CD34-positive) are related lesions, and that there might possibly be a continuum between the two. In addition, NTF exhibits CD99 positivity. It was therefore, hypothesized that both DFSP and GCF would show similar immunopositivity for CD99. Archives of pathology at several institutions were searched for DFSP and GCF tissue blocks. A total of 29 DFSP and 5 GCF were analyzed by immunohistochemistry for expression of CD99. Twenty-three of 29 DFSP (79%) and 2 of 5 GCP (40%) expressed CD99. Comparison of CD99 and CD34 showed that the non-tumoral periphery of DFSP was less probable to be CD99 positive, but this finding was not statistically significant.

摘要

根据大多数作者的观点，隆突性皮肤纤维肉瘤（DFSP）和巨细胞成纤维细胞瘤（GCF）分别代表同一疾病实体的成人和青少年形式，相似的形态、相同的染色体易位以及CD34阳性均可证明这一点。研究表明，DFSP和项部纤维瘤（NTF）（其同样CD34阳性）是相关病变，二者之间可能存在连续谱。此外，NTF表现为CD99阳性。因此，有人提出假设，DFSP和GCF对CD99会表现出相似的免疫阳性。检索了几家机构的病理学档案，寻找DFSP和GCF组织块。对总共29例DFSP和5例GCF进行免疫组织化学分析，以检测CD99的表达情况。29例DFSP中有23例（79%）表达CD99，5例GCP中有2例（40%）表达CD99。CD99和CD34的比较显示，DFSP的非肿瘤周边区域CD99阳性的可能性较小，但这一发现无统计学意义。