针对高敏受者的协作移植研究肾脏交换试验
Collaborative Transplant Study Kidney Exchange Trial for highly sensitized recipients.
作者信息
Opelz G
机构信息
Department of Transplantation Immunology, University of Heidelberg, Germany.
出版信息
Clin Transpl. 1991:61-4.
PMID:1820146
Abstract
- A better than 70% 1-year graft success rate was obtained in highly sensitized recipients of first and second kidney transplants. Recipients of third or fourth transplants had a 25% lower success rate. 2. The results of this trial show a strong influence of HLA matching in highly sensitized recipients. HLA-DR mismatches appear to be most deleterious, followed by HLA-B mismatches. 3. Thirty transplants with 0 mismatches for HLA-B, -DR had an excellent 88% 1-year graft survival rate. 4. The strong effect of HLA matching mandates the national and international exchange of kidneys for highly sensitized recipients.
摘要
- 在首次和第二次肾移植的高敏受者中，获得了超过70%的1年移植成功率。第三次或第四次移植的受者成功率低25%。2. 该试验结果显示HLA配型对高敏受者有很大影响。HLA-DR错配似乎最有害，其次是HLA-B错配。3. 30例HLA-B、-DR无错配的移植手术有出色的88%的1年移植存活率。4. HLA配型的显著作用要求在国内和国际上为高敏受者交换肾脏。
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