益肝散治疗抗精神病药物所致迟发性运动障碍：一项开放性研究。
Yi-gan san for the treatment of neuroleptic-induced tardive dyskinesia: an open-label study.
作者信息
Miyaoka Tsuyoshi, Furuya Motohide, Yasuda Hideaki, Hayashida Maiko, Nishida Akira, Inagaki Takuji, Horiguchi Jun
机构信息
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo, 693-8501, Japan.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):761-4. doi: 10.1016/j.pnpbp.2007.12.003. Epub 2007 Dec 14.
BACKGROUND
Recent studies indicate that the traditional Japanese herbal medicine yi-gan san (YGS, yokukan-san in Japanese), a serotonin modulator, may be safe and useful in treating behavioral and psychological symptoms in dementia and borderline personality disorder patients. The authors examined the efficacy, tolerability, and safety of YGS in patients with tardive dyskinesia.
METHODS
Twenty-two patients with schizophrenia who had neuroleptic-induced tardive dyskinesia were given 7.5 g/day of YGS for 12 weeks in an open-label study.
RESULTS
Administration of YGS resulted in a statistically significant improvement in tardive dyskinesia and psychotic symptoms.
CONCLUSIONS
YGS may be an effective and safe therapy to control tardive dyskinesia and psychosis in patients with schizophrenia, that should be further tested in double-blind, placebo-controlled trials.
背景
近期研究表明，传统日本草药抑肝散（YGS，日语为 yokukan-san）作为一种血清素调节剂，在治疗痴呆症和边缘性人格障碍患者的行为及心理症状方面可能是安全且有效的。作者研究了抑肝散对迟发性运动障碍患者的疗效、耐受性和安全性。
方法
在一项开放标签研究中，22 名患有抗精神病药物所致迟发性运动障碍的精神分裂症患者每天服用 7.5 克抑肝散，持续 12 周。
结果
服用抑肝散使迟发性运动障碍和精神病性症状有了统计学上的显著改善。
结论
抑肝散可能是控制精神分裂症患者迟发性运动障碍和精神病的一种有效且安全的疗法，应在双盲、安慰剂对照试验中进一步检验。
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