Ting Ka Ka, Brew Bruce, Guillemin Gilles
Centre for Immunology, St. Vincent's Hospital, Darlinghurst 2010, Sydney, NSW, Australia.
Neurotox Res. 2007 Dec;12(4):247-62. doi: 10.1007/BF03033908.
The kynurenine pathway (KP) and several of its neuroactive products, especially quinolinic acid (QUIN), are considered to be involved in the neuropathogenesis of Alzheimer's disease (AD). There is growing evidence suggesting that astrocytes play a critical role in the regulation of the excitotoxicity and inflammatory processes that occur during the evolution of AD. This review focuses on the role of astrocytes through their relation with the KP to the different features associated with AD including cytokine, chemokine and adhesion molecule production, cytoskeletal changes, astrogliosis, excitotoxicity, apoptosis and neurodegeneration.
犬尿氨酸途径（KP）及其几种神经活性产物，尤其是喹啉酸（QUIN），被认为与阿尔茨海默病（AD）的神经发病机制有关。越来越多的证据表明，星形胶质细胞在AD进展过程中发生的兴奋性毒性和炎症过程的调节中起关键作用。本综述重点关注星形胶质细胞通过其与KP的关系在与AD相关的不同特征中的作用，包括细胞因子、趋化因子和黏附分子的产生、细胞骨架变化、星形胶质细胞增生、兴奋性毒性、细胞凋亡和神经退行性变。
