Ingersoll Karen S, Cohen Jessye
Department of Psychiatry and Neurobehavioral Science, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, USA.
J Behav Med. 2008 Jun;31(3):213-24. doi: 10.1007/s10865-007-9147-y. Epub 2008 Jan 19.
This article reviews recent literature in chronic illness or long-term health management including asthma, contraception, diabetes, HIV disease, and hypertension/cardiovascular disease, mental disorders, pain, and other diseases to determine the relationship between regimen factors and adherence to medications. The authors conducted an electronic literature search to detect articles published between 1998 and 2007. Articles were included if they pertained to a chronic illness or to contraception, included a clear definition of how adherence was measured, and included regimen factors as primary or secondary explanatory variables. Methodology of the studies varied greatly, as did methods of measuring adherence and regimen factors. Surprisingly few of these articles concerned (1) chronic treatment, (2) regimen factors such as dosing, pill burden, and regimen complexity, and (3) adherence measured in a clear manner. Most studies failed to use state-of-the-art methods of measuring adherence. Despite these flaws, a suggestive pattern of the importance of regimen factors, specifically dose frequency and regimen complexity, emerged from this review.
本文回顾了近期关于慢性病或长期健康管理的文献，涵盖哮喘、避孕、糖尿病、艾滋病、高血压/心血管疾病、精神障碍、疼痛及其他疾病，以确定治疗方案因素与药物依从性之间的关系。作者进行了电子文献检索，以查找1998年至2007年间发表的文章。若文章涉及慢性病或避孕、对依从性测量方法有明确界定且将治疗方案因素作为主要或次要解释变量，则纳入研究。研究方法差异很大，测量依从性和治疗方案因素的方法亦是如此。令人惊讶的是，这些文章中很少涉及（1）长期治疗，（2）诸如给药剂量、服药负担和治疗方案复杂性等治疗方案因素，以及（3）以明确方式测量的依从性。大多数研究未能采用最先进的依从性测量方法。尽管存在这些缺陷，但本次综述仍呈现出治疗方案因素（尤其是给药频率和治疗方案复杂性）重要性的提示性模式。
