14C-赭曲霉毒素A和14C-赭曲霉毒素B在大鼠体内的分布：基于全身放射自显影的比较
Distribution of 14C-ochratoxin A and 14C-ochratoxin B in rats: a comparison based on whole-body autoradiography.
作者信息
Breitholtz Emanuelsson A, Fuchs R, Hult K, Appelgren L E
机构信息
Department of Biochemistry and Biotechnology, Royal Institute of Technology, Stockholm, Sweden.
出版信息
IARC Sci Publ. 1991(115):201-3.
PMID:1820334
Abstract
The distribution patterns of ochratoxin A and its nontoxic dechloro-analogue ochratoxin B were studied in rats using whole-body autoradiography. No prominent difference in distribution patterns was found that could explain why the rat is the animal most susceptible to ochratoxin A-induced renal cancer or why ochratoxin B is less toxic than ochratoxin A.
摘要
利用全身放射自显影技术，在大鼠体内研究了赭曲霉毒素A及其无毒的脱氯类似物赭曲霉毒素B的分布模式。未发现分布模式存在显著差异，这无法解释为何大鼠是最易受赭曲霉毒素A诱发肾癌影响的动物，也无法解释为何赭曲霉毒素B的毒性低于赭曲霉毒素A。
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