氟代“外消旋”混合物合成：用于同时分离和对映体拆分外消旋氟代标记化合物的多糖基手性柱
Fluorous "racemic" mixture synthesis: polysaccharide-based chiral columns for simultaneous demix and enantioseparation of racemic fluorous tagged compounds.
作者信息
Tonoi Takayuki, Zhang Wei, Curran Dennis P, Mikami Koichi
机构信息
Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo, Japan.
出版信息
Chirality. 2008 Mar;20(3-4):597-603. doi: 10.1002/chir.20487.
The proof of concept experiments of fluorous "racemic" mixture synthesis (FRMS) is shown using polysaccharide-based chiral stationary phases. The mixture of racemic O-benzoylmandelate derivatives bearing different lengths of fluorous cleavable tags undergoes sequential reactions to provide individual derivatives as well as their enantiomers resolved on polysaccharide-based chiral HPLC columns (DAICEL CHIRALCEL and CHIRALPAK series).
使用基于多糖的手性固定相展示了氟代“外消旋”混合物合成（FRMS）的概念验证实验。带有不同长度氟代可裂解标签的外消旋O-苯甲酰基扁桃酸酯衍生物混合物经过一系列反应，以提供在基于多糖的手性HPLC柱（大赛璐手性拆分柱CHIRALCEL和CHIRALPAK系列）上分离出的各个衍生物及其对映体。
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