Tonoi Takayuki, Zhang Wei, Curran Dennis P, Mikami Koichi
Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo, Japan.
Chirality. 2008 Mar;20(3-4):597-603. doi: 10.1002/chir.20487.
The proof of concept experiments of fluorous "racemic" mixture synthesis (FRMS) is shown using polysaccharide-based chiral stationary phases. The mixture of racemic O-benzoylmandelate derivatives bearing different lengths of fluorous cleavable tags undergoes sequential reactions to provide individual derivatives as well as their enantiomers resolved on polysaccharide-based chiral HPLC columns (DAICEL CHIRALCEL and CHIRALPAK series).
使用基于多糖的手性固定相展示了氟代“外消旋”混合物合成（FRMS）的概念验证实验。带有不同长度氟代可裂解标签的外消旋O-苯甲酰基扁桃酸酯衍生物混合物经过一系列反应，以提供在基于多糖的手性HPLC柱（大赛璐手性拆分柱CHIRALCEL和CHIRALPAK系列）上分离出的各个衍生物及其对映体。
