海吡咯类化合物，一种源自海洋链霉菌属的具有前所未有的结构类型的抗生素。
The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp.
作者信息
Hughes Chambers C, Prieto-Davo Alejandra, Jensen Paul R, Fenical William
机构信息
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, USA.
出版信息
Org Lett. 2008 Feb 21;10(4):629-31. doi: 10.1021/ol702952n. Epub 2008 Jan 19.
Abstract
Cultivation of an obligate marine Streptomyces strain has furnished the marinopyrroles A and B, densely halogenated, axially chiral metabolites that contain an uncommon bispyrrole structure. X-ray analysis of marinopyrrole B showed that the natural product exists as an atropo-enantiomer with the M-configuration. Though configurationally stable at room temperature, M-(-)-marinopyrrole A can be racemized at elevated temperatures to yield the non-natural P-(+)-atropo-enantiomer. The marinopyrroles possess potent antibiotic activities against methicillin-resistant Staphylococcus aureus.
摘要
一种专性海洋链霉菌菌株的培养产生了海生吡咯A和B，它们是高度卤代的、具有轴手性的代谢产物，含有不常见的双吡咯结构。海生吡咯B的X射线分析表明，该天然产物以M构型的阻转对映体形式存在。虽然M-(-)-海生吡咯A在室温下构型稳定，但在高温下会发生消旋化，生成非天然的P-(+)-阻转对映体。海生吡咯对耐甲氧西林金黄色葡萄球菌具有强大的抗菌活性。
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