Charan Romila D, Schlingmann Gerhard, Bernan Valerie S, Feng Xidong, Carter Guy T
Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, USA.
J Nat Prod. 2005 Feb;68(2):277-9. doi: 10.1021/np0496542.
Along with dioxapyrrolomycin (1), four new pyrrolomycin antibiotics, namely, pyrrolomycin G (3), pyrrolomycin H (4), pyrrolomycin I (5), and pyrrolomycin J (6), were produced in cultures of Streptomyces fumanus. Apart from dioxapyrrolomycin, pyrrolomycin G and pyrrolomycin H are the only other chiral members of the pyrrolomycin family of antibiotics, and their absolute stereochemistry was deduced to be 13S. Here, we report the isolation, structure elucidation, and antimicrobial activity of these new pyrrolomycins.
除了二氧吡咯霉素（1）之外，在富马链霉菌培养物中还产生了四种新的吡咯霉素抗生素，即吡咯霉素G（3）、吡咯霉素H（4）、吡咯霉素I（5）和吡咯霉素J（6）。除二氧吡咯霉素外，吡咯霉素G和吡咯霉素H是吡咯霉素类抗生素中仅有的其他手性成员，它们的绝对立体化学结构被推导为13S。在此，我们报道了这些新吡咯霉素的分离、结构解析及抗菌活性。
