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使用洗必泰浸渍贴片于针孔部位以降低局部发病率:ChIPPS 试点试验

Use of chlorhexidine-impregnated patch at pin site to reduce local morbidity: the ChIPPS Pilot Trial.

作者信息

Wu Stephanie C, Crews Ryan T, Zelen Charles, Wrobel James S, Armstrong David G

机构信息

Scholl's Center for Lower Extremity Ambulatory Research (CLEAR), Rosalind Franklin University of Medicine, Chicago, IL 60064, USA.

出版信息

Int Wound J. 2008 Jun;5(3):416-22. doi: 10.1111/j.1742-481X.2007.00368.x. Epub 2008 Jun 1.

Abstract

Pin tract infection is one of the most common complications associated with the use of external fixation. While some studies have identified the potential benefit of chlorhexidine gluconate-impregnated polyurethane dressings to reduce the incidence of catheter-related bloodstream infections, we are unaware of any published studies that evaluate the effectiveness of similar technologies in reducing the risk for external-fixation-related pin tract infections. Therefore, the purpose of this study was to evaluate the effectiveness of chlorhexidine gluconate-impregnated polyurethane dressing in reducing percutaneous-device-related skin colonisation and local infections. In this initial retrospective cohort, data were abstracted for two groups of consecutive patients undergoing surgery involving external fixation at an interdisciplinary foot and ankle surgical unit. All patients received surgical treatment of their foot/ankle pathology along with application of a hybrid external fixator. Twenty patients (45% male, age 54.5 +/- 3.69 years) received chlorhexidine gluconate-impregnated polyurethane dressing and twenty (55% male, age 55.8 +/- 3.22 years) received standard pin care. There was a significantly higher rate of pin tract infection in patients who received standard pin care compared with those who received chlorhexidine gluconate-impregnated polyurethane dressings (25% versus 0%, P = 0.047). There was no significant difference in any of the descriptive study characteristics (age, gender, diabetes and presence of neuropathy). The results of this initial study suggest that chlorhexidine gluconate-impregnated polyurethane dressing may be effective to reduce the incidence of pin tract infections and help decrease morbidity associated with external fixation.

摘要

针道感染是与外固定器使用相关的最常见并发症之一。虽然一些研究已确定葡萄糖酸氯己定浸渍的聚氨酯敷料在降低导管相关血流感染发生率方面的潜在益处,但我们尚未发现有任何已发表的研究评估类似技术在降低外固定相关针道感染风险方面的有效性。因此,本研究的目的是评估葡萄糖酸氯己定浸渍的聚氨酯敷料在减少经皮装置相关皮肤定植和局部感染方面的有效性。在这项初始回顾性队列研究中,提取了在一个跨学科足踝外科单元接受涉及外固定手术的两组连续患者的数据。所有患者均接受了足/踝病变的手术治疗,并应用了混合外固定器。20名患者(45%为男性,年龄54.5±3.69岁)接受了葡萄糖酸氯己定浸渍的聚氨酯敷料,20名患者(55%为男性,年龄55.8±3.22岁)接受了标准的针护理。接受标准针护理的患者针道感染率显著高于接受葡萄糖酸氯己定浸渍的聚氨酯敷料的患者(25%对0%,P = 0.047)。在任何描述性研究特征(年龄、性别、糖尿病和神经病变的存在)方面均无显著差异。这项初步研究的结果表明,葡萄糖酸氯己定浸渍的聚氨酯敷料可能有效降低针道感染的发生率,并有助于降低与外固定相关的发病率。

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