格雷夫斯病患者中的偶然甲状腺癌
Incidental thyroid carcinoma in patients with Graves' disease.
作者信息
Phitayakorn Roy, McHenry Christopher R
机构信息
Department of Surgery, MetroHealth Medical Center, Case Western Reserve University School of Medicine, 2500 MetroHealth Dr., Cleveland, OH 44109, USA.
出版信息
Am J Surg. 2008 Mar;195(3):292-7; discussion 297. doi: 10.1016/j.amjsurg.2007.12.006.
BACKGROUND
The clinical significance of incidental thyroid carcinoma in patients with Graves' disease is uncertain.
METHODS
The prevalence of incidental thyroid carcinoma was determined in patients with Graves' disease who underwent surgery from 1990 to 2007 and was compared with patients with nontoxic nodular goiter or toxic multinodular goiter who underwent surgery during the same time period.
RESULTS
Of the 93 patients who underwent thyroidectomy for Graves' disease, 2 patients (2.2%) had an incidental papillary carcinoma: .4 and .5 cm in size. Neither patient developed recurrent disease after 3 and 13 years of follow-up evaluation. The prevalence of incidental thyroid cancer was 3.6% and 6.2% in patients with nontoxic nodular goiter and toxic multinodular goiter, respectively (P = not significant).
CONCLUSIONS
The prevalence of incidental thyroid carcinoma in patients with Graves' disease is comparable with patients with nontoxic or toxic goiter. Incidental thyroid carcinomas in patients with Graves' disease were papillary microcarcinomas of no clinical consequence.
背景
格雷夫斯病患者中偶然发现的甲状腺癌的临床意义尚不确定。
方法
确定1990年至2007年接受手术的格雷夫斯病患者中偶然发现甲状腺癌的患病率，并与同期接受手术的非毒性结节性甲状腺肿或毒性多结节性甲状腺肿患者进行比较。
结果
在93例因格雷夫斯病接受甲状腺切除术的患者中，2例（2.2%）偶然发现乳头状癌，大小分别为0.4厘米和0.5厘米。在3年和13年的随访评估后，这两名患者均未出现疾病复发。非毒性结节性甲状腺肿和毒性多结节性甲状腺肿患者中偶然发现甲状腺癌的患病率分别为3.6%和6.2%（P值无统计学意义）。
结论
格雷夫斯病患者中偶然发现甲状腺癌的患病率与非毒性或毒性甲状腺肿患者相当。格雷夫斯病患者中偶然发现的甲状腺癌为无临床意义的乳头状微小癌。
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