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[甲状腺病理学中的偶然癌:我们的经验及文献综述]

[Incidental carcinoma in thyroid pathology: our experience and review of the literature].

作者信息

Pezzolla Angela, Lattarulo Serafina, Milella Marialessia, Barile Graziana, Pascazio Bianca, Ciampolillo Anna, Fabiano Gennaro, Palasciano Nicola

机构信息

Dipartimento dell'Emergenza e dei Trapianti di Organi, Università degli Studi di Bari, Bari.

出版信息

Ann Ital Chir. 2010 May-Jun;81(3):165-9.

Abstract

The diagnosis of incidental thyroid carcinoma in patients submitted to thyroidectomy for a benign disease is quite frequent. A retrospective analysis was performed on 240 patients submitted to surgical intervention in order to establish the incidence of the carcinoma. One hundred sixty five patients (68.75%) were affected by benign disease (132 multinodular goiter, 30 uninodular goiter, 2 Plummer and 1 Basedow) and 75 (31.25%) by carcinoma. In 30 of 165 patients (18.2 %), affected by benign disease, occurred a histological diagnosis of thyroid carcinoma, (18 papillary carcinoma, 6 follicular carcinoma, 5 papillary carcinoma follicular variant and 1 oncocytic carcinoma). In this study it's considered incidental thyroid carcinoma the one occurred in patients who never underwent FNA and there were no suspicious features in all exams that may suggest the presence of carcinoma. Fifteen of the 30 incidental carcinoma (50%) were microcarcinomas; in the other 13, dimensions were more than 1 cm, but less than 2 cm in 9 cases. Two patients had a synchronous carcinoma. Actually these patients are still in a follow up program and no recurrency of disease is occasionally observed. This study shows that the only way to put doubts on the real benignity of the disease is the fine needle aspiration; there are no other instruments that could let think about the occurrence of the carcinoma. Moreover in the majority of cases the incidental carcinoma is a microcarcinoma, it doesn't reach significant volume, may be not centered by a FNAB, but in must cases it's not really biologically aggressive.

摘要

因良性疾病接受甲状腺切除术的患者中,偶然发现甲状腺癌的诊断相当常见。对240例接受手术干预的患者进行了回顾性分析,以确定癌症的发生率。165例(68.75%)患者患有良性疾病(132例结节性甲状腺肿、30例单结节性甲状腺肿、2例普卢默病和1例巴塞多氏病),75例(31.25%)患有癌症。在165例患有良性疾病的患者中,有30例(18.2%)经组织学诊断为甲状腺癌(18例乳头状癌、6例滤泡状癌、5例乳头状癌滤泡状变异型和1例嗜酸细胞癌)。在本研究中,偶然发现的甲状腺癌是指从未接受过细针穿刺活检(FNA)且所有检查中均无提示癌症存在的可疑特征的患者中发生的癌症。30例偶然发现的癌症中有15例(50%)为微小癌;在另外13例中,肿瘤大小超过1 cm,但9例小于2 cm。2例患者有同步癌。实际上,这些患者仍在随访计划中,偶尔未观察到疾病复发。这项研究表明,对疾病真正的良性产生怀疑的唯一方法是细针穿刺活检;没有其他手段能够让人想到癌症的发生。此外,在大多数情况下,偶然发现的癌症是微小癌,它没有达到显著体积,可能未被FNA检出,但在大多数情况下它在生物学上并非真正具有侵袭性。

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