Bouron-Dal Soglio Dorothée, Truong Françoise, Fetni Raouf, Hazourli Sawcene, Champagne Josette, Oligny Luc Laurier, Fournet Jean-Christophe
Department of Pathology, Centre Hospitalo-Universitaire Sainte-Justine, 3175 chemin de la Côte Sainte-Catherine, Montréal, Québec, Canada H3T 1C5.
Hum Pathol. 2008 Feb;39(2):292-7. doi: 10.1016/j.humpath.2007.08.002.
Progressive transformation of germinal center (PTGC) is a pattern of lymph node reactive hyperplasia. It can also be the predominant pattern in a hyperplastic lymph node known as florid PTGC. It is characterized histologically by the expansion of the mantle zone lymphocytes into both the adjacent sinusoids and germinal centers. The lymphocytes destroying the germinal centers are predominantly B cells, with a minor population of T cells. Morphologically, it can be confused with nodular lymphocyte-predominant Hodgkin disease (NLPHD) because of its nodular pattern and because of the presence of large cells that can be incorrectly identified as lymphocytic and histiocytic cells. A relationship between PTGC and NLPHD remains unclear, and many authors have suggested that PTGC can represent a precursor lesion of NLPHD. Here we report the first karyotype obtained in PTGC, in a 12-year-old boy. It shows a t(3;22)(q27;q11) translocation, probably involving the BCL6 gene. This translocation has previously been described in diffuse large B-cell lymphomas and in NLPHD with BCL6 rearrangement. This finding offers an insight into a possible tumorigenic pathway from PTGC to NLPHD. Further studies will be required to confirm this hypothesis.
生发中心进行性转化（PTGC）是一种淋巴结反应性增生模式。它也可以是增生性淋巴结中称为 florid PTGC 的主要模式。其组织学特征是套区淋巴细胞向相邻的窦状隙和生发中心扩展。破坏生发中心的淋巴细胞主要是 B 细胞，还有少量 T 细胞。形态学上，由于其结节状模式以及存在可被错误识别为淋巴细胞和组织细胞的大细胞，它可能与结节性淋巴细胞为主型霍奇金淋巴瘤（NLPHD）混淆。PTGC 与 NLPHD 之间的关系仍不清楚，许多作者认为 PTGC 可能代表 NLPHD 的前驱病变。在此，我们报告了一名 12 岁男孩 PTGC 的首个核型。它显示 t(3;22)(q27;q11)易位，可能涉及 BCL6 基因。这种易位先前已在弥漫性大 B 细胞淋巴瘤和伴有 BCL6 重排的 NLPHD 中描述过。这一发现为从 PTGC 到 NLPHD 的可能致瘤途径提供了见解。需要进一步研究来证实这一假设。
