Blancato J N
United States Environmental Protection Agency Office of Research and Development, Environmental Monitoring Systems Laboratory, Las Vegas, Nevada.
Ann Ist Super Sanita. 1991;27(4):601-8.
Pharmacokinetic non-linearities occur between different doses and between different species. Physiologically based pharmacokinetic models are accurate tools for taking these non-linearities into account. Dichloromethane and perchloroethylene are two examples discussed in this paper. For dichloromethane the pharmacokinetic non-linearity factor results in a greater delivered dose than would be predicted from linear relationships as the dose increases. For perchloroethylene the opposite holds true. In addition a brief illustration of the use of pharmacokinetic models as tools for interpreting biomarker data is provided.
不同剂量之间以及不同物种之间会出现药代动力学非线性。基于生理的药代动力学模型是考虑这些非线性的精确工具。二氯甲烷和全氯乙烯是本文讨论的两个例子。对于二氯甲烷，药代动力学非线性因素导致随着剂量增加，实际递送剂量比根据线性关系预测的剂量更大。对于全氯乙烯，情况则相反。此外，还简要说明了药代动力学模型作为解释生物标志物数据工具的用途。
