Nonomura N
Department of Otolaryngology, Niigata University School of Medicine, Japan.
Auris Nasus Larynx. 1991;18(4):323-9. doi: 10.1016/s0385-8146(12)80225-2.
Phagocytic cells in middle ear effusion obtained from patients with acute or chronic otitis media, have antibacterial activity which is an element of the host defense system. In addition, they modify inflammatory responses as they release degranulated substances, phospholipid-derived substances, and active oxygens. To demonstrate both the direct and indirect biological activities of chemotactic factor through migrating inflammatory phagocytic cells in acute otitis media, a synthetic chemotactic peptide, formyl-methionyl-leucyl-phenylalanine (fmlp), was inoculated into the middle ear of guinea pigs. Fmlp induced severe vascular damage, mucosal edema, and infiltration of phagocytic cells 1 and 3 days after inoculation and interstitial fibrosis and calcification 2 weeks after inoculation. Chemotactic factor in the middle ear cavity caused middle ear tissue damage and may play a role in the development of acute and chronic otitis media.
从急性或慢性中耳炎患者中耳积液中获取的吞噬细胞具有抗菌活性，这是宿主防御系统的一个组成部分。此外，它们在释放脱颗粒物质、磷脂衍生物质和活性氧时会改变炎症反应。为了通过急性中耳炎中迁移的炎性吞噬细胞来证明趋化因子的直接和间接生物学活性，将一种合成趋化肽甲酰甲硫氨酰亮氨酰苯丙氨酸（fmlp）接种到豚鼠中耳。接种后1天和3天，fmlp引起严重的血管损伤、粘膜水肿和吞噬细胞浸润，接种后2周引起间质纤维化和钙化。中耳腔内的趋化因子导致中耳组织损伤，可能在急性和慢性中耳炎的发展中起作用。
