O'Driscoll C M, O'Reilly J R, Corrigan O I
University of Dublin, Dept. of Pharmaceutics, School of Pharmacy, Trinity College, Ireland.
Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:116-9.
All simple micellar systems investigated, containing both naturally occurring and synthetic surfactants, enhanced the solubility of clofazimine. The incorporation of fatty acid to form mixed micelles, brought about a further enhancement in drug solubility in the case of naturally occurring surfactants, in contrast, with synthetic surfactants this enhancement decreased. The most effective absorption promoter was a synthetic surfactant: fatty acid mixed micellar system. The results indicate an optimum surfactant: fatty acid ratio at which the solubility and membrane effects of the surfactant system are balanced.
