Périgny Martine, Bairati Isabelle, Harvey Isabelle, Beauchemin Michel, Harel François, Plante Marie, Têtu Bernard
Department of Pathology, Centre Hospitalier Universitaire de Québec, l'Hôtel-Dieu de Québec, Canada.
Am J Clin Pathol. 2008 Feb;129(2):226-31. doi: 10.1309/49LA9XCBGWJ8F2KM.
Matrix metalloproteinases (MMPs) are enzymes thought to be involved in tumor invasion. We hypothesized that MMP-2 and MMP-11 overexpression was associated with the aggressiveness of ovarian carcinoma. This study was performed on samples from 100 patients with stage III ovarian carcinomas treated surgically between 1990 and 2000. Immunohistochemical staining was performed on ovarian tumors and peritoneal implants using monoclonal antibodies. Overexpression was defined as more than 10% of cells expressing the marker. Multivariate analyses showed that only MMP-2 overexpression by cancer cells in peritoneal implants was associated with a significant risk of death by disease (hazard ratio, 2.65; 95% confidence interval, 1.41-4.97; P =.003). MMP-11 overexpression was not predictive of survival. These results suggest that MMP-2 overexpression by cancer cells in peritoneal implants and not in the primary ovarian cancer is predictive of ovarian cancer prognosis and more likely reflects the presence of particularly aggressive clones of cancer cells.
基质金属蛋白酶（MMPs）是一类被认为与肿瘤侵袭有关的酶。我们推测MMP - 2和MMP - 11的过表达与卵巢癌的侵袭性相关。本研究对1990年至2000年间接受手术治疗的100例III期卵巢癌患者的样本进行。使用单克隆抗体对卵巢肿瘤和腹膜种植灶进行免疫组织化学染色。过表达定义为表达该标志物的细胞超过10%。多因素分析显示，仅腹膜种植灶中癌细胞的MMP - 2过表达与疾病死亡的显著风险相关（风险比，2.65；95%置信区间，1.41 - 4.97；P = 0.003）。MMP - 11过表达不能预测生存情况。这些结果表明，腹膜种植灶而非原发性卵巢癌中癌细胞的MMP - 2过表达可预测卵巢癌预后，且更可能反映存在特别具有侵袭性的癌细胞克隆。
