巴比妥N-葡萄糖苷未被检测到是巴比妥在人体尿液中的排泄产物。

Barbital N-glucoside is not detected as a urinary excretion product of barbital in humans.

作者信息

Soine W H, Soine P J, England T M

机构信息

Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond 23298-0540.

出版信息

J Pharm Biomed Anal. 1991;9(9):747-52. doi: 10.1016/0731-7085(91)80216-v.

DOI:10.1016/0731-7085(91)80216-v

PMID:1821152

Abstract

A study was undertaken to determine if humans excreted barbital N-glucoside as a urinary metabolite following oral administration of barbital. A liquid chromatography method using gradient elution was developed for detecting and quantifying barbital N-glucoside and barbital in urine. Following a single oral dose of barbital to male caucasian and oriental subjects that had previously been shown to excrete amobarbital and phenobarbital N-glucosides, no barbital N-glucoside conjugate was observed in the urine. This result indicates that N-glucosylation of barbiturates is not a general pathway for the biodisposition of barbiturates in man.

摘要

开展了一项研究，以确定人类在口服巴比妥后是否会将巴比妥N-葡萄糖苷作为尿液代谢物排出。开发了一种使用梯度洗脱的液相色谱方法，用于检测和定量尿液中的巴比妥N-葡萄糖苷和巴比妥。在先前已显示会排泄异戊巴比妥和苯巴比妥N-葡萄糖苷的男性白种人和东方受试者单次口服巴比妥后，尿液中未观察到巴比妥N-葡萄糖苷共轭物。该结果表明，巴比妥类药物的N-葡萄糖基化不是巴比妥类药物在人体内生物转化的一般途径。