2-磷酸酒石酸酯对糖酵解酶的抑制作用。
Inhibition of glycolytic enzymes by 2-phosphotartronate.
作者信息
Thomas M K, Spring T G
出版信息
Biochem J. 1976 Mar 1;153(3):741-4. doi: 10.1042/bj1530741.
Abstract
2-Phosphotartronate has been synthesized by permanganate oxidation of glycerol 2-phosphate and has been tested as an inhibitor of five glycolytic enzymes that bind phosphoglycerate or phosphoglycollate. Competitive inhibition of rabbit muscle phosphoglycerate mutase, enolase and pyruvate kinase was observed. Triose phosphate isomerase and 3-phosphoglycerate kinase were not inhibited.
摘要
通过甘油2-磷酸的高锰酸盐氧化合成了2-磷酸酒石酸，并作为结合磷酸甘油酸或磷酸乙醇酸的五种糖酵解酶的抑制剂进行了测试。观察到对兔肌肉磷酸甘油酸变位酶、烯醇化酶和丙酮酸激酶的竞争性抑制。磷酸丙糖异构酶和3-磷酸甘油酸激酶未被抑制。
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本文引用的文献
1
Separation of the phosphoric esters on the filter paper chromatogram.磷酸酯在滤纸色谱上的分离
Nature. 1949 Dec 31;164(4183):1107-12, illust. doi: 10.1038/1641107a0.
2
Crystalline 3-phosphoglycerate kinase from skeletal muscle.来自骨骼肌的结晶3-磷酸甘油酸激酶。
Biochem J. 1969 Jul;113(3):551-4. doi: 10.1042/bj1130551.
3
The isolation and crystallization of yeast and rabbit liver triose phosphate isomerase and a comparative characterization with the rabbit muscle enzyme.酵母和兔肝磷酸丙糖异构酶的分离与结晶以及与兔肌肉酶的比较表征
Eur J Biochem. 1970 Jun;14(2):289-300. doi: 10.1111/j.1432-1033.1970.tb00289.x.
4
Stereoselective interactions of phosphoenolpyruvate analogues with phosphoenolpyruvate-utilizing enzymes.磷酸烯醇丙酮酸类似物与利用磷酸烯醇丙酮酸的酶之间的立体选择性相互作用。
J Biol Chem. 1970 Nov 25;245(22):6057-64.
5
Isolation and characterization of rabbit muscle triose phosphate isomerase.
Biochemistry. 1970 Dec 8;9(25):4952-8. doi: 10.1021/bi00827a019.
6
Studies on two high-affinity enolase inhibitors. Chemical characterization.
Biochemistry. 1971 Dec 7;10(25):4649-54. doi: 10.1021/bi00801a009.
7
Studies on two high-affinity enolase inhibitors. Reaction with enolases.
Biochemistry. 1971 Dec 7;10(25):4655-60. doi: 10.1021/bi00801a010.
8
Formation of an active phosphoenzyme by diphosphoglycerate-dependent phosphoglyceromutases from muscle, kidney and yeast.由来自肌肉、肾脏和酵母的二磷酸甘油酸依赖性磷酸甘油变位酶形成活性磷酸酶。
Biochim Biophys Acta. 1972 Dec 7;289(2):311-22. doi: 10.1016/0005-2744(72)90082-4.
9
Nuclear magnetic resonance studies of selectively hindered internal motion of substrate analogs at the active site of pyruvate kinase.丙酮酸激酶活性位点处底物类似物选择性受阻内部运动的核磁共振研究。
Biochemistry. 1972 Jul 18;11(15):2813-8. doi: 10.1021/bi00765a013.
10
A direct spectrophotometric assay for pyruvate kinase.丙酮酸激酶的直接分光光度测定法。
Anal Biochem. 1967 May;19(2):272-9. doi: 10.1016/0003-2697(67)90163-7.
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