Starkstein S E, Bryer J B, Berthier M L, Cohen B, Price T R, Robinson R G
Department of Psychiatry and Behavioral Sciences and Neurosciences, Johns Hopkins University School of Medicine, Baltimore.
J Neuropsychiatry Clin Neurosci. 1991 Summer;3(3):276-85. doi: 10.1176/jnp.3.3.276.
The pattern of brain asymmetries was visualized on computed tomography (CT) scan in patients with a single acute cerebrovascular lesion. Patients were divided into those with typical or reversed frontal and/or occipital asymmetries. Among patients with a typical occipital asymmetry, those with left frontal or left basal ganglia lesions showed a significantly higher frequency of major depression and significantly higher depression scores than patients with similar lesion location but with reversed occipital asymmetry or those with a typical asymmetry and lesions in other (left or right) brain areas. Among patients with a reversed occipital asymmetry, there was no significant association between left frontal or left basal ganglia lesions and depression. This study demonstrates that the previously reported significant association between post-stroke major depression and lesion location is restricted to patients with a typical occipital asymmetry and is not present in patients with a reversed occipital asymmetry.
在患有单一急性脑血管病变的患者中，通过计算机断层扫描（CT）观察大脑不对称模式。患者被分为具有典型或反转的额叶和/或枕叶不对称的患者。在具有典型枕叶不对称的患者中，与具有相似病变位置但枕叶不对称反转的患者或具有典型不对称且病变位于其他（左或右）脑区的患者相比，左额叶或左基底节病变的患者出现重度抑郁症的频率显著更高，抑郁评分也显著更高。在枕叶不对称反转的患者中，左额叶或左基底节病变与抑郁症之间没有显著关联。这项研究表明，先前报道的中风后重度抑郁症与病变位置之间的显著关联仅限于具有典型枕叶不对称的患者，而在枕叶不对称反转的患者中不存在。
