Linke Georg R, Zerz Andreas, Tutuian Radu, Marra Francesco, Warschkow Rene, Müller-Stich Beat P, Borovicka Jan
Department of Surgery, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland.
J Gastrointest Surg. 2008 May;12(5):816-21. doi: 10.1007/s11605-008-0470-6. Epub 2008 Jan 23.
Laparoscopic fundoplication is the standard antireflux procedure. However, side effects such as gas bloating indicate that the procedure is not unproblematic. Laparoscopic mesh-augmented hiatoplasty (LMAH) might be an alternative operation aimed at restoring the intra-abdominal part of the esophagus and reducing the size of the diaphragmatic hiatus.
The aim of this study was to prospectively evaluate gastroesophageal reflux disease symptoms and gastroesophageal reflux before and after LMAH using 24 h impedance-pH monitoring (MII-pH).
Twenty patients underwent MII-pH monitoring pre- and 3 months post-LMAH. Symptoms were assessed using the Gastrointestinal Symptom Rating Scale questionnaire.
LMAH reduced the mean (SD) reflux syndrome score [pre-op 4.5 (1.7) vs post-op 1.4 (0.9); p<0.001], median (25th-75th percentile) distal %time pH<4 [4.9 (3.4-10.3) vs 1.0 (0.3-2.5) %; p=0.001) and total number of liquid reflux episodes [27.5 (17.5-38.3) vs 18 (7.3-29.3); p<0.05] without changing the number of gas reflux episodes [12 (6-34.3) vs 13.5 (6-20); p=0.346). All patients reported no limitation of their ability to belch.
LMAH significantly reduces reflux symptoms and esophageal acid exposure without interfering with the ability to vent gas from the stomach documented by an unchanged number of gas reflux episodes before and after LMAH.
腹腔镜胃底折叠术是标准的抗反流手术。然而,诸如气体腹胀等副作用表明该手术并非毫无问题。腹腔镜网状增强裂孔成形术(LMAH)可能是一种旨在恢复食管腹段并缩小膈裂孔大小的替代手术。
本研究的目的是使用24小时阻抗 - pH监测(MII - pH)前瞻性评估LMAH术前和术后的胃食管反流病症状及胃食管反流情况。
20例患者在LMAH术前和术后3个月接受MII - pH监测。使用胃肠道症状评分量表问卷评估症状。
LMAH降低了平均(标准差)反流综合征评分[术前4.5(1.7)vs术后1.4(0.9);p<0.001],中位(第25 - 75百分位数)远端pH<4的时间百分比[4.9(3.4 - 10.3)vs 1.0(0.3 - 2.5)%;p = 0.001]以及液体反流发作总数[27.5(17.5 - 38.3)vs 18(7.3 - 29.3);p<0.05],而气体反流发作次数未改变[12(6 - 34.3)vs 13.5(6 - 20);p = 0.346]。所有患者均报告嗳气能力无受限。
LMAH显著减轻反流症状和食管酸暴露,且不影响胃内气体排出能力,LMAH前后气体反流发作次数未变即证明了这一点。