Zerbib F, des Varannes S Bruley, Roman S, Pouderoux P, Artigue F, Chaput U, Mion F, Caillol F, Verin E, Bommelaer G, Ducrotté P, Galmiche J-P, Sifrim D
Gastroenterology Department, Saint André Hospital, Bordeaux, France.
Aliment Pharmacol Ther. 2005 Nov 15;22(10):1011-21. doi: 10.1111/j.1365-2036.2005.02677.x.
Impedance-pH monitoring is the most sensitive method for detection and characterization of gastro-oesophageal reflux episodes. Normal values from European subjects are lacking.
To build a database of gastro-oesophageal reflux patterns from French and Belgian healthy subjects.
Seventy-two healthy subjects (35 men, mean age 35 years, 18-72) underwent 24-h ambulatory impedance-pH studies. Gastro-oesophageal reflux episodes were detected using impedance and characterized by pH as acid, weakly acidic, or weakly alkaline. Analysis was performed visually and effects of age, gender and intra-individual reproducibility were evaluated.
The total number of gastro-oesophageal reflux episodes was 44 (25,58,75) of which 59% were acid, 28% were weakly acidic and 10% weakly alkaline. Half of gastro-oesophageal reflux episodes were mixed (liquid/gas) and 22% reached 15 cm above the lower oesophageal sphincter. The bolus clearance time was 11 s while acid was chemically cleared in 34 s. Male gender was associated with increased number and proximal extent of total and acid gastro-oesophageal reflux. Repeated studies in 27 subjects showed good reproducibility for number, acidity and air-liquid composition of reflux (Kendall's W-values = 0.72-0.85).
This study demonstrates good reproducibility of 24-h ambulatory impedance-pH studies and provides values of reflux patterns in healthy subjects for comparisons with European gastro-oesophageal reflux disease patients.
阻抗 - pH监测是检测和表征胃食管反流发作的最敏感方法。目前缺乏来自欧洲受试者的正常值。
建立一个来自法国和比利时健康受试者的胃食管反流模式数据库。
72名健康受试者（35名男性，平均年龄35岁，年龄范围18 - 72岁）接受了24小时动态阻抗 - pH研究。使用阻抗检测胃食管反流发作，并根据pH值将其表征为酸性、弱酸性或弱碱性。进行了视觉分析，并评估了年龄、性别和个体内重复性的影响。
胃食管反流发作的总数为44次（25、58、75），其中59%为酸性，28%为弱酸性，10%为弱碱性。一半的胃食管反流发作是混合性的（液体/气体），22%的反流发作到达食管下括约肌上方15厘米处。团块清除时间为11秒，而酸在34秒内被化学清除。男性与总的和酸性胃食管反流发作的次数增加及近端范围扩大有关。对27名受试者进行的重复研究显示，反流发作的次数、酸度和气液成分具有良好的重复性（肯德尔W值 = 0.72 - 0.85）。
本研究证明了24小时动态阻抗 - pH研究具有良好的重复性，并提供了健康受试者反流模式的值，以便与欧洲胃食管反流病患者进行比较。
