Alexopoulos George S, Raue Patrick J, Kanellopoulos Dora, Mackin Scott, Arean Patricia A
Department of Psychiatry, Weill Cornell Medical College, White Plains, NY 10605, USA.
Int J Geriatr Psychiatry. 2008 Aug;23(8):782-8. doi: 10.1002/gps.1988.
The 'depression executive dysfunction syndrome' afflicts a considerable number of depressed elderly patients and may be resistant to conventional pharmacotherapy. Non-pharmacological approaches addressing their behavioral deficits may reduce disability and experienced stress and improve depression.
This paper focuses on problem solving therapy (PST) because it targets concrete problems that can be understood by patients with executive dysfunction and trains patients to address them using an easy to comprehend structured approach.
We suggest that PST is a suitable treatment for patients with the depression-executive dysfunction syndrome because it has been found effective in uncomplicated geriatric major depression and in other psychiatric disorders accompanied by severe executive dysfunction. Furthermore, PST can address specific clinical features of depressed patients with executive dysfunction, especially when modified to address difficulties with affect regulation, initiation and perseveration.
A preliminary study suggests that appropriately modified PST improves problem solving skills, depression and disability in elderly patients with the depression-executive dysfunction syndrome of late life. If these findings are confirmed, PST may become a therapeutic option for a large group of depressed elderly patients likely to be drug resistant.
“抑郁执行功能障碍综合征”困扰着相当数量的老年抑郁症患者,且可能对传统药物治疗有抗性。针对其行为缺陷的非药物方法可能会减少残疾和减轻压力,并改善抑郁症状。
本文聚焦于问题解决疗法(PST),因为它针对执行功能障碍患者能够理解的具体问题,并训练患者使用易于理解的结构化方法来解决这些问题。
我们认为PST适合治疗抑郁执行功能障碍综合征患者,因为它已被证明对单纯性老年重度抑郁症以及伴有严重执行功能障碍的其他精神障碍有效。此外,PST可以解决伴有执行功能障碍的抑郁症患者的特定临床特征,特别是当进行调整以解决情感调节、启动和坚持方面的困难时。
一项初步研究表明,适当调整后的PST可提高患有晚年抑郁执行功能障碍综合征的老年患者的问题解决能力、改善抑郁症状并减少残疾。如果这些发现得到证实,PST可能会成为一大群可能对药物有抗性的老年抑郁症患者的一种治疗选择。