锌膏与结核菌素皮肤试验的可靠性
Zinc cream and reliability of tuberculosis skin testing.
作者信息
Rao V Bhargavi, Pelly Tom F, Gilman Robert H, Cabrera Lilia, Delgado Jose, Soto Giselle, Friedland Jon S, Escombe A Roderick, Black Robert E, Evans Carlton A
机构信息
Imperial College London, London, UK.
出版信息
Emerg Infect Dis. 2007 Jul;13(7):1101-4. doi: 10.3201/eid1307.070227.
In 50 healthy Peruvian shantytown residents, zinc cream applied to tuberculosis skin-test sites caused a 32% increase in induration compared with placebo cream. Persons with lower plasma zinc had smaller skin-test reactions and greater augmentation with zinc cream. Zinc deficiency caused false-negative skin-test results, and topical zinc supplementation augmented antimycobacterial immune responses enough to improve diagnosis.
在50名健康的秘鲁棚户区居民中，与使用安慰剂乳膏相比，在结核菌素皮肤试验部位涂抹锌乳膏使硬结增加了32%。血浆锌水平较低的人皮肤试验反应较小，使用锌乳膏后的增强作用更大。锌缺乏导致皮肤试验结果出现假阴性，局部补充锌可增强抗分枝杆菌免疫反应，足以改善诊断。
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