Scita Giorgio, Confalonieri Stefano, Lappalainen Pekka, Suetsugu Shiro
IFOM (FIRC Institute for Molecular Oncology) - Foundation, Via Adamello 16, 20139 Milan, Italy; School of Medicine, University of Milan, 20122 Milan, Italy.
Trends Cell Biol. 2008 Feb;18(2):52-60. doi: 10.1016/j.tcb.2007.12.002. Epub 2008 Jan 22.
A tight spatiotemporal coordination of the machineries controlling membrane bending and trafficking, and actin dynamics is crucial for the generation of cellular protrusions. Proteins that are simultaneously capable of regulating actin dynamics and sensing or inducing membrane curvature are predicted to have a prominent role. A prototypical example of this type of proteins is the insulin receptor tyrosine kinase substrate of 53kDa, the founding member of a recently discovered family of proteins, including missing-in-metastasis and ABBA (actin-bundling protein with BAIAP2 homology). Structural, biochemical and cell biological experiments support the unique role of this family as transducers of signalling, linking the protruding membrane to the underlying actin cytoskeleton.
控制膜弯曲、运输的机制与肌动蛋白动力学之间紧密的时空协调，对于细胞突起的形成至关重要。预计同时能够调节肌动蛋白动力学并感知或诱导膜曲率的蛋白质将发挥重要作用。这类蛋白质的一个典型例子是53kDa的胰岛素受体酪氨酸激酶底物，它是最近发现的一个蛋白质家族的创始成员，该家族还包括转移缺失蛋白和ABBA（与BAIAP2具有同源性的肌动蛋白束蛋白）。结构、生化和细胞生物学实验支持了这个家族作为信号转导分子的独特作用，将突出的膜与下面的肌动蛋白细胞骨架联系起来。
