Institute of Biotechnology, University of Helsinki, P.O. Box 56 (Viikinkaari 9), 00014 Helsinki, Finland.
Curr Opin Cell Biol. 2011 Feb;23(1):14-21. doi: 10.1016/j.ceb.2010.10.005. Epub 2010 Nov 17.
Dynamic plasma membrane rearrangements occur during many cellular processes including endocytosis, morphogenesis, and migration. Actin polymerization together with proteins that directly deform membranes, such as the BAR superfamily proteins, is essential for generation of membrane invaginations during endocytosis. Importantly, recent studies revealed that direct membrane deformation contributes also to the formation of plasma membrane protrusions such as filopodia and lamellipodia. Inverse BAR (I-BAR) domain proteins bind phosphoinositide-rich membrane with high affinity and generate negative membrane curvature to induce plasma membrane protrusions. I-BAR domain proteins, such as IRSp53, MIM, ABBA, and IRTKS also harbor many protein-protein interaction modules that link them to actin dynamics. Thus, I-BAR domain proteins may connect direct membrane deformation to actin polymerization in cell morphogenesis and migration.
在许多细胞过程中，如内吞作用、形态发生和迁移，都会发生动态的质膜重排。肌动蛋白聚合以及直接变形膜的蛋白质，如 BAR 超家族蛋白，对于内吞作用期间质膜凹陷的产生是必不可少的。重要的是，最近的研究表明，直接的膜变形也有助于形成质膜突起，如丝状伪足和片状伪足。反向 BAR（I-BAR）结构域蛋白与富含磷酸肌醇的膜高亲和力结合，并产生负膜曲率以诱导质膜突起。I-BAR 结构域蛋白，如 IRSp53、MIM、ABBA 和 IRTKS，还具有许多蛋白质-蛋白质相互作用模块，将它们与肌动蛋白动力学联系起来。因此，I-BAR 结构域蛋白可能将直接的膜变形与细胞形态发生和迁移中的肌动蛋白聚合联系起来。
