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Lymphocytes, B lymphocytes, and clonal CLL cells: observations on the impact of the new diagnostic criteria in the 2008 Guidelines for Chronic Lymphocytic Leukemia (CLL).淋巴细胞、B淋巴细胞和克隆性慢性淋巴细胞白血病（CLL）细胞：关于2008年慢性淋巴细胞白血病（CLL）指南中新诊断标准影响的观察
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Health-related quality of life in younger patients with chronic lymphocytic leukemia treated with fludarabine plus cyclophosphamide or fludarabine alone for first-line therapy: a study by the German CLL Study Group.氟达拉滨联合环磷酰胺或单用氟达拉滨一线治疗年轻慢性淋巴细胞白血病患者的健康相关生活质量：德国慢性淋巴细胞白血病研究组的一项研究
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3
International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia.慢性淋巴细胞白血病流式细胞术残留病监测的国际标准化方法
Leukemia. 2007 May;21(5):956-64. doi: 10.1038/sj.leu.2404584. Epub 2007 Mar 15.
4
Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia.腹部计算机断层扫描可预测 Rai 0 期慢性淋巴细胞白血病患者的病情进展。
J Clin Oncol. 2007 Apr 20;25(12):1576-80. doi: 10.1200/JCO.2006.08.4194. Epub 2007 Mar 12.
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Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia.初治慢性淋巴细胞白血病患者总生存的预后列线图及指数
Blood. 2007 Jun 1;109(11):4679-85. doi: 10.1182/blood-2005-12-051458. Epub 2007 Feb 13.
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Comprehensive assessment of genetic and molecular features predicting outcome in patients with chronic lymphocytic leukemia: results from the US Intergroup Phase III Trial E2997.预测慢性淋巴细胞白血病患者预后的遗传和分子特征综合评估：美国协作组III期试验E2997的结果
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Revised response criteria for malignant lymphoma.恶性淋巴瘤修订后的反应标准。
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Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus.慢性淋巴细胞白血病异基因干细胞移植的指征：欧洲血液与骨髓移植学会移植共识
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Due to low infection rates no routine anti-infective prophylaxis is required in younger patients with chronic lymphocytic leukaemia during fludarabine-based first line therapy.由于感染率较低，年轻的慢性淋巴细胞白血病患者在基于氟达拉滨的一线治疗期间无需进行常规抗感染预防。
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慢性淋巴细胞白血病诊断与治疗指南：慢性淋巴细胞白血病国际研讨会报告，更新美国国立癌症研究所工作组1996年指南

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines.

作者信息

Hallek Michael, Cheson Bruce D, Catovsky Daniel, Caligaris-Cappio Federico, Dighiero Guillaume, Döhner Hartmut, Hillmen Peter, Keating Michael J, Montserrat Emili, Rai Kanti R, Kipps Thomas J

机构信息

Klinik I für Innere Medizin, Universität zu Köln, Köln, Germany.

出版信息

Blood. 2008 Jun 15;111(12):5446-56. doi: 10.1182/blood-2007-06-093906. Epub 2008 Jan 23.

DOI:10.1182/blood-2007-06-093906
PMID:18216293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2972576/
Abstract

Standardized criteria for diagnosis and response assessment are needed to interpret and compare clinical trials and for approval of new therapeutic agents by regulatory agencies. Therefore, a National Cancer Institute-sponsored Working Group (NCI-WG) on chronic lymphocytic leukemia (CLL) published guidelines for the design and conduct of clinical trials for patients with CLL in 1988, which were updated in 1996. During the past decade, considerable progress has been achieved in defining new prognostic markers, diagnostic parameters, and treatment options. This prompted the International Workshop on Chronic Lymphocytic Leukemia (IWCLL) to provide updated recommendations for the management of CLL in clinical trials and general practice.

摘要

需要标准化的诊断和反应评估标准来解释和比较临床试验，并供监管机构批准新的治疗药物。因此，一个由美国国立癌症研究所赞助的慢性淋巴细胞白血病（CLL）工作组（NCI-WG）在1988年发布了CLL患者临床试验设计和实施的指南，并于1996年进行了更新。在过去十年中，在确定新的预后标志物、诊断参数和治疗选择方面取得了相当大的进展。这促使慢性淋巴细胞白血病国际研讨会（IWCLL）为临床试验和一般临床实践中CLL的管理提供更新的建议。