Scandling John D, Busque Stephan, Dejbakhsh-Jones Sussan, Benike Claudia, Millan Maria T, Shizuru Judith A, Hoppe Richard T, Lowsky Robert, Engleman Edgar G, Strober Samuel
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
N Engl J Med. 2008 Jan 24;358(4):362-8. doi: 10.1056/NEJMoa074191.
We describe a recipient of combined kidney and hematopoietic-cell transplants from an HLA-matched donor. A post-transplantation conditioning regimen of total lymphoid irradiation and antithymocyte globulin allowed engraftment of the donor's hematopoietic cells. The patient had persistent mixed chimerism, and the function of the kidney allograft has been normal for more than 28 months since discontinuation of all immunosuppressive drugs. Adverse events requiring hospitalization were limited to a 2-day episode of fever with neutropenia. The patient has had neither rejection episodes nor clinical manifestations of graft-versus-host disease.
我们描述了一名接受来自 HLA 配型相合供体的肾和造血细胞联合移植的受者。采用全身淋巴照射和抗胸腺细胞球蛋白的移植后预处理方案使供体造血细胞得以植入。该患者持续存在混合嵌合体，自停用所有免疫抑制药物以来，同种异体肾移植功能已正常超过 28 个月。需要住院治疗的不良事件仅限于伴有中性粒细胞减少的 2 天发热期。该患者既没有发生排斥反应，也没有移植物抗宿主病的临床表现。
