Gage F H, Kang U J, Fisher L J
Department of Neurosciences, University of California, San Diego, La Jolla 92093-0624.
Curr Opin Neurobiol. 1991 Oct;1(3):414-9. doi: 10.1016/0959-4388(91)90063-d.
A review of work in the dopaminergic system reveals both progress and controversy. More than 100 papers on intracerebral grafting were published last year. Several groups have published the clinical outcome of fetal substantia nigra implants in Parkinsonian patients and studies suggest that sprouting of dopaminergic fibers in response to grafting procedures ameliorates the behavioral deficits of dopamine-depleted animals. Trophic factors for dopamine neurons have also been identified. In addition, genetically modified cells continue to be developed as an alternative method for delivering molecules to the brain. The speed with which neural grafting has become a therapeutic procedure in Parkinsonian patients continues to stimulate debate.
对多巴胺能系统的研究工作回顾显示既有进展也有争议。去年发表了100多篇关于脑内移植的论文。几个研究小组公布了帕金森病患者胎儿黑质植入的临床结果，研究表明，移植过程中多巴胺能纤维的芽生改善了多巴胺缺乏动物的行为缺陷。多巴胺神经元的营养因子也已被确定。此外，转基因细胞作为向大脑输送分子的替代方法也在不断发展。神经移植在帕金森病患者中迅速成为一种治疗方法，这一点仍在引发争论。
