肌营养不良蛋白研究的最新进展。
Recent advances in dystrophin research.
作者信息
Rojas C V, Hoffman E P
机构信息
Department of Molecular Genetics, University of Pittsburgh School of Medicine, Pennsylvania 15261.
出版信息
Curr Opin Neurobiol. 1991 Oct;1(3):420-9. doi: 10.1016/0959-4388(91)90064-e.
PMID:1821686
Abstract
Evidence suggesting that dystrophin is a component of the membrane cytoskeleton of excitable cells continues to accumulate. Whereas the specific mechanisms leading to muscle pathology in Duchenne muscular dystrophy are still being debated it is apparent that the progressive weakness that occurs in this disease is the result of a chronic process that is initiated by dystrophin deficiency.
摘要
越来越多的证据表明，肌营养不良蛋白是可兴奋细胞的膜细胞骨架的一个组成部分。虽然导致杜氏肌营养不良症肌肉病变的具体机制仍在争论中，但很明显，这种疾病中出现的进行性肌无力是由肌营养不良蛋白缺乏引发的慢性过程的结果。
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