Kasper S, Kick H, Voll G, Vieira A
Psychiatric Department, University of Bonn, Germany.
Eur Neuropsychopharmacol. 1991 May;1(2):107-11. doi: 10.1016/0924-977x(91)90711-3.
Although there is a body of literature on the therapeutic efficacy of sleep deprivation (SD) there are only a few investigations in which the relevance of antidepressive medication for the clinical efficacy of SD has been studied. Based on the literature and on our own investigations with major depressed patients it seems that for the day-1 response it does not matter if and what type of antidepressive medication the patient receives. Furthermore, the results of our double blind study reveal that the day-1 response to total sleep deprivation (TSD) is not associated with a clear relationship to the outcome after 4 weeks treatment with either fluvoxamine or maprotiline. On the other hand, our data indicate that the day-2 response to TSD is significantly correlated with a beneficial outcome after subchronic treatment with maprotiline.
虽然有大量关于睡眠剥夺（SD）治疗效果的文献，但仅有少数研究探讨了抗抑郁药物对SD临床疗效的相关性。基于文献以及我们对重度抑郁症患者的自身研究，似乎对于第1天的反应而言，患者是否接受以及接受何种类型的抗抑郁药物并无影响。此外，我们双盲研究的结果显示，第1天对完全睡眠剥夺（TSD）的反应与使用氟伏沙明或马普替林治疗4周后的结果并无明确关联。另一方面，我们的数据表明，第2天对TSD的反应与马普替林亚慢性治疗后的有益结果显著相关。
